Relationship between spontaneous echo contrast in the thoracic aorta and plasma von Willebrand factor |
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Authors: | Takuya Inoue Makoto Suzuki Atsushi Namiki Hironori Hirai Kaoru Sugi |
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Institution: | (1) Department of Cardiovascular Medicine, Toho University Ohashi Medical Center, 2-17-6 Ohashi, Meguro, Tokyo 153-8515, Japan;(2) Center for Clinical Training and Education, Toho University, Tokyo, Japan |
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Abstract: | Purpose To clarify the relationships between spontaneous echo contrast (SEC) detected by transesophageal echocardiography (TEE) and
coagulopathy, ultrasonographic findings that may correlate to biochemical coagulation markers were examined.
Methods TEE was performed on 49 consecutive patients (mean age 64 ± 14 years; 28 men, 21 women). Blood samples were taken at the same
time as TEE was carried out. Aortic SEC (Ao-SEC) and left atrial SEC (LA-SEC) were classified into three grades: absent, mild
and marked. Levels of von Willebrand factor (vWF), thrombin antithrombin III complex (TAT), prothrombin fragments 1+2 (F1+2)
and fibrinopeptide A (FPA) were measured.
Results Mean plasma vWF levels by Ao-SEC grade were 144 ± 39% for absent, 177 ± 55% for mild and 210 ± 73% for marked, with significantly
higher levels in the Ao-SEC marked group than in the Ao-SEC absent group (P < 0.05). Mean plasma vWF levels by LA-SEC were 185 ± 73% for absent, 180 ± 49% for mild and 201 ± 62% for marked, with no
significant differences apparent between groups. Moreover, no relationships were identified between Ao-SEC grade and plasma
levels of coagulation indicators TAT, F1+2 and FPA.
Conclusion Plasma vWF levels correlated to grade of aortic SEC. Characteristics of the coagulation system differ between Ao-SEC and LA-SEC.
Ao-SEC offers a clinical indicator of platelet thrombus formation. |
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Keywords: | transesophageal echocardiography von Willebrand factor spontaneous echo contrast aorta |
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