| 阿糖胞苷、二甲基亚砜对HL-60细胞周期动力学的影响 |
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| 引用本文： | 石海,张宝凤,王昭礼. 阿糖胞苷、二甲基亚砜对HL-60细胞周期动力学的影响[J]. 沈阳药科大学学报, 1990, 0(4) |
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| 作者姓名： | 石海 张宝凤 王昭礼 |
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| 作者单位： | 吉林省医药工业研究所(石海)，沈阳药学院药理教研室(张宝凤)，吉林省医药工业研究所(王昭礼) |
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| 摘 要： | 本文应用流式细胞仪技术研究了二甲基亚砜(DMSO)、阿糖胞苷(Ara-c)诱导HL-60分化成熟过程中,细胞周期动力学的变化。结果表明DMSO、Ara-c作用3天后,具有S、G_2期DNA含量的细胞占全部细胞的百分率,在DMSO组减小,而Ara-c组略有增加。
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| 关 键 词： | 细胞分化 Ara-c DMSO |
EFFECTS OF DSMO ARA-C ON CELL CYCLE KINETICS OF HL-60 CELLS |
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| Shi Hai,Zhang Baofeng,Wang Zhaoli. EFFECTS OF DSMO ARA-C ON CELL CYCLE KINETICS OF HL-60 CELLS[J]. Journal of Shenyang Pharmaceutical University, 1990, 0(4) |
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| Authors: | Shi Hai Zhang Baofeng Wang Zhaoli |
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| Affiliation: | Shi Hai,Zhang Baofeng,Wang Zhaoli,Department of Pharmacology |
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| Abstract: | It has been reported previously that HL-60 cells were induced to matu-rity along granulocytic and monocytic cells by using 1.1% dimetyl sulfoxideand 5×10~(-7)M 1-D-arabinofuranosylcytosine. We used FCM technique instudying the changes of cell population after induction. DNA histogramshowed that 3days after being induced by DMSO there was a decrease in thenumber of cells with S or G_2 DNA and the number of cells with S andG_2DNA remained steady after being induced by 1-D-arabinofuranosylcytosine |
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| Keywords: | Cell differentiation Ara-C DMSO |
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