| Abstract: | The prenatal and postnatal carcinogenic action of orthoaminoazotoluene (OAAT) on the liver was studied in CBA mice. The carcinogen was administered to the mice by the gastric route in oily solution in three doses each of 4 mg (total 12 mg). Tumors of the liver were found 12 months after administration of OAAT in the postnatal period in females in 89.3% of cases compared with 11.5% in the control and in males in 78.7% of cases compared with 68.5% in the control. In the experimental progenies exposed to OAAT during the last 4–5 days of prenatal development tumors of the liver were found in females at the age of 12 months in 54.8% of cases compared with 5.3% in the control and in males in 81.1% of cases compared with 35.2% in the control. In the experimental progenies, especially in males, malignant neoplasms were found more often than in intact animals or those exposed to OAAT in the postnatal period.Department of Carcinogenic Agents, Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR L. M. Shabad.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 2, pp. 199–202, February, 1978. |
