热毒宁注射液对竹叶青蛇咬伤患者INR、PT以及APTT等凝血指标水平变化的影响

目的：研究热毒宁注射液（RI）对竹叶青蛇（TS）咬伤患者国际标准化比率（INR）、凝血酶原时间（PT）以及活化部分促凝血酶原激酶时间（APTT）等凝血指标水平变化的影响。方法选择该院2010年7月至2013年7月收治的TS咬伤患者300例进行观察。分2组，对照组实施常规治疗，观察组另加RI进行治疗。对比两组症状改善情况，疗效以及INR、PT和APTT凝血指标变化情况。结果观察组肿胀消退时间是（127．8±56．2）h，止痛时间是（5．3±2．7）h，住院时间是（3．8±2．7）d；较对照组的（150．3±83．4）h、（11．5±6．1）h、（5．8±4．4）d，明显更短。两组病患治疗后INR，PT以及APTT均出现延长，且观察组延长程度低于对照组。观察组痊愈率为90．00％（135／150），愈显率为98．00％（147／150），较对照组的67．33％（101／150），84．67％（127／150）明显更高，差异均有统计学意义（P＜0．05）。结论RI治疗TS咬伤，疗效显著，能有效缩短症状改善时间，抑制因TS咬伤引起的凝血指标延长。

Effect of Reduning injection on INR,PT and APTT levels in patients with Trimeresurus stejnegeri bite

Objective To investigate the effect of Reduning injection(RI)on international normalized ratio(INR) ,prothrombin time(PT)and activated partial thromboplastin time(APTT)levels in patients with Trimeresurus stejnegeri(TS)bite .Methods Three hundred cases of patients with TS bite in our hospital from July 2010 to July 2013 were randomly divided into 2 groups .The control group received the routine treatment while the observation group treated with RI besides ,and then compared the growth of symptoms ,effect and changes of INR ,PT and APTT of 2 groups .Results The observation group′s swelling time (127 .8 ± 56 .2) h] ,analgesic time (5 .3 ± 2 .7)h] ,hospitalization time (3 .8 ± 2 .7)d] was lower than those of the control group (150 .3 ± 83 .4) h ,(11 .5 ± 6 .1)h ,(5 .8 ± 4 .4)d] .The INR ,PT and APTT of 2 groups after treatment were both extended .However ,the extended degree of observation group was much lower .The observation group′s cure rate 90 .00% (135/150)] ,markedly effective rate 98 .00% (147/150)]were higher than those of the control group 67 .33% (101/150) ,84 .67% (127/150)] ,which showed statisti‐cally significant difference(P<0 .05) .Conclusion RI shows good effect on curing TS bite patients and could effectively shorten the time for symptom improvement and inhibit the prolonged coagulation index .