时间-空间标记反转脉冲序列在测量中脑导水管脑脊液的应用

目的：采用磁共振成像（MRI）时间‐空间标记反转脉冲序列测量不同年龄组正常人中脑导水管的脑脊液峰值流速，探讨脑脊液的流动规律。方法选取健康志愿者41例，年龄7～73岁；其中男23例，女18例，按不同年龄分为4组：7～＜15岁组（n＝11），15～＜35岁组（n＝10），35～＜45岁组（n＝9），≥45岁组（n＝11），应用东芝1．5TMRI8通道头颅线圈，采用MRItime‐SLIP序列标记脑脊液，计算出中脑导水管内脑脊液的峰值流速；测量中脑导水管的内径及长度。结果中脑导水管脑脊液峰值流速，15～＜35岁组与35～＜45岁组，≥45岁组，与7～＜15岁组比较差异均有统计学意义（P＜0．05）；中脑导水管的内径和长度在不同年龄组差异无统计学意义（P＞0．05）。结论在中脑导水管，脑脊液呈双向流动；MRItime‐SLIP序列能实时定量测量脑脊液的流速，能显示脑脊液的湍流。

Research of normal cerebrospinal fluid flow of the middle aqueduct by spin labeling at MR imaging

Objective To measure the normal cerebrospinal fluid of the midbrain aqueduct peak velocity of different age groups by using magnetic resonance imaging (MRI) time‐spatial labeling inversion pulse (time‐SLIP) ,and to discuss the flow law of CSF . Methods Forty‐one cases of healthy volunteers ,including 23 cases of male ,18 cases of female ,aged 7 -73 .Patients were divided into 4 groups:7- <15 age group (n=11) ,15- <35 age group (n=10) ,35- <45 age group (n=9) ,≥45 age group (n=11) .We used the application of Toshiba 1 .5 T MRI head coil ,MRI sequence of time‐SLIP marked CSF to calculated the peak velocity of CSF in the midbrain aqueduct and measure the diameter and length of the midbrain aqueduct .Results The peak flow velocity be‐tween the 7- <15 age group and 15 - <35 age group ,35 - <45 age group ,≥45 age group were statistically significant (P<0 .05);inner diameter and length were no statistically significant difference (P>0 .05) between age .Conclusion In the midbrain aqueduct ,CSF is two‐way flow and supports the CSF of the pulsatile flow theory ;MRI sequence of time‐SLIP could measure CSF velocity and display the turbulence fluiding .