丙酮酸乙酯对大鼠重症急性胰腺炎肾损伤的保护作用 |
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引用本文: | 杨恒,吕和平,周蒙滔,张启瑜.丙酮酸乙酯对大鼠重症急性胰腺炎肾损伤的保护作用[J].肝胆胰外科杂志,2011,23(2):89-91,95. |
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作者姓名: | 杨恒 吕和平 周蒙滔 张启瑜 |
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作者单位: | 温州医学院第一附属医院肝胆外科,浙江,温州,325000 |
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摘 要: | 目的 探讨丙酮酸乙酯对大鼠重症急性胰腺炎(SAP)肾损伤的治疗作用及其机制.方法 72只大鼠随机分为假手术组(S组),SAP组(P组)、丙酮酸乙酯治疗组(T组).大鼠SAP模型由5%牛磺胆酸钠胆胰管逆行注射诱发而成.各组于术后3、6、12 h检测血清中肿瘤坏死因子(TNF)-α、白细胞介素(IL)-6、高迁移率族蛋白B...
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关 键 词: | 重症急性胰腺炎 丙酮酸乙酯 肾损伤 高迁移率族蛋白B1 核因子-κB 大鼠 |
Protective effect of ethyl pyruvate on renal injury in severe acute pancreatitis rats |
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Institution: | YANG Heng,LV He-ping,ZHOU Meng-tao,et al.Department of Hepatobiliary Surgery,the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000 |
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Abstract: | Objective To explore the therapeutic role and its mechanism of ethyl pyruvate on renal injury induced by severe acute pancreatitis(SAP) in rats.Methods Seventy-two SD rats were randomly divided into three groups: sham operation group(S group),SAP group(P group) and ethyl pyruvate treatment group(T group).SAP model was established by retrograde infusion of 50 g/L sodium taurocholate into the biliopancreatic duct of rats.The rats were killed at 3 h,6 h and 12 h after operation.The serum level of TNF-α,IL-6,BUN,Cr and HMGB-1 were measured.The expression of NF-κB was detected by immunohistochemistry.The renal tissues were taken for HE staining and electron microscopic examination.Results In group P,serum levels of TNF-α,IL-6,BUN,Cr and expression of NF-κB in the renal tissues were higher than those in group S(P<0.05),HMGB-1 levels were higher than those in group S at 6 h and 12 h(P<0.05).The serum level of TNF-α,IL-6,BUN,Cr,HMGB-1 and expression of NF-κB in the renal tissues in T group were lower than those in group P(P<0.05).Renal pathological damage was milder in group T than those in group P under microscopy and electron microscopy.Conclusion Ethyl pyruvate plays a protective role against renal injury in severe acute pancreatitis rats.The underlying mechanism may be related to inhibition of TNF-α,IL-6,HMGB-1 and suppression of NF-κB. |
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Keywords: | severe acute pancreatitis ethyl pyruvate renal injure high mobility group box-1 nuclear factor-κappaB rats |
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