人乳头瘤病毒感染患者性功能障碍发生状况及影响因素分析

目的:研究人乳头瘤病毒(human papilloma virus,HPV)感染女性性功能障碍(female sexual dysfunction,FSD)发生状况及相关影响因素。方法:选取2019年5-7月在首都医科大学附属北京妇产医院妇瘤科门诊就诊的HPV阳性患者300例作为研究对象,通过填写一般问卷及女性性功能指数量表(FSFI)收集资料,分析HPV感染患者FSD发生现状及相关影响因素。结果:300例患者中,FSD发生率为81.00%(243/300),平均FSFI评分为(17.34±9.73)分。在性功能的6个维度中,出现障碍的比例由高到低依次是性欲低下(82.00%)、性满意度下降(69.00%)、性唤起困难(66.67%)、性高潮障碍(62.33%)、性交疼痛(52.00%)、阴道润滑困难(49.33%)。不同年龄、文化程度、职业、收入、焦虑与否的HPV感染患者FSD发生率差异有统计学意义(均P<0.05)。Logistic回归分析显示,年龄>40岁(OR=7.747,95%CI:3.329~18.030,P<0.001)、高中/大专及以下学历(OR=4.029,95%CI:1.540~10.542,P=0.005)、焦虑(OR=4.028,95%CI:1.713~9.472,P=0.001)是HPV感染患者发生FSD的独立影响因素。结论:HPV感染患者的FSD发生率较高,其FSFI评分明显降低,性功能的6个维度中,性欲低下的发生率最高。对于年龄>40岁、高中/大专及以下学历以及合并焦虑的HPV感染患者应尤其重视,早期识别并给予干预,改善其生活质量。

Influencing Factors of Sexual Dysfunction in Women with Human Papilloma Virus Infection

Objective: To study the incidence of female sexual dysfunction(FSD) and its influencing factors in women with human papilloma virus(HPV) infection. Methods: From May to July 2019, 300 HPV-positive patients were investigated using the general questionnaire and Female Sexual Function Index(FSFI). The FSD and related factors in those HPV-infected patients were analyzed. Results: Among 300 HPV-infected patients, the incidence of FSD was 81.00%(243/300), and the FSFI score was 17.34±9.73. Among the six dimensions of sexual function, the proportions of disorders from high to low were low sexual desire(82.00%), the decreased sexual satisfaction(69.00%), difficulty in arousing sex(66.67%), orgasm disorder(62.33%), sexual pain(52.00%) and vaginal lubrication difficulty(49.33%). There was significant difference in the incidence of FSD among the HPVinfected patients of different age, education level, occupation, income and anxiety(P<0.05). Logistic regression analysis showed that age >40 years old(OR=7.747, 95%CI: 3.329-18.030, P<0.001), high school/college degree and below(OR=4.029, 95%CI: 1.540-10.542, P=0.005), anxiety(OR=4.028, 95%CI: 1.713-9.472, P=0.001) were independent factors of FSD. Conclusions:The incidence of FSD in patients with HPV infection was higher, and the FSFI score was significantly lower. Among the six dimensions of sexual function, the incidence of low sexual desire was the highest. For those patients with age >40 years old, high school/college degree or below and anxiety, we should pay special attention to early identification and intervention to improve their quality of life.