维生素D与早产儿呼吸窘迫综合征的临床分析

目的分析早产儿血清维生素D[25-(OH)D3]水平与早产儿呼吸窘迫综合征(RDS)发生的相关性,为早产儿RDS的治疗提供科学依据。方法选取2018年9月-2019年3月在武汉大学人民医院新生儿科住院的131例RDS早产儿为实验组,29例非RDS早产儿为对照组。收集所有患儿一般临床资料(性别、分娩方式、母孕情况及Apgar评分等)及血清25-(OH)D3结果,分析25-(OH)D3水平与RDS发生之间的关系。结果 RDS组25-(OH)D3水平低于对照组,差异均有统计学意义(t=2.682,P<0.05),且CPAP时间、吸氧时间、静脉营养天数、住院天数均明显高于对照组,差异均有统计学意义(t=2.969、2.380、2.571、1.999,P<0.05)。Logistic回归分析显示:维生素D缺乏是早产儿发生RDS的危险因素(OR=0.050,95%CI:0.013~0.186,P<0.05)。结论早产儿更易发生维生素D缺乏,且维生素D缺乏可能是早产儿RDS发生的危险因素,预防维生素D缺乏有重大意义。

Clinical analysis of vitamin D and respiratory distress syndrome in preterm infants

Objective To analyze the relationship between serum vitamin D [25- (OH)D₃] levels at birth and respiratory distress syndrome (RDS) in preterm infants,in order to provide scientific basis for the treatment of RDS in preterm infant. Methods A total of 131 premature infants with RDS admitted to the Wuhan University People′s Hospital were selected as the experimental group,and 29 non-RDS premature infants were used as control group.The clinical data (such as gender,mode of delivery,maternal pregnancy and Apgar score)and the results of serum 25- (OH) D₃ were collected,and the association between serum 25- (OH)D₃ level and RDS was analyzed. Results 25- (OH)D₃ levels in the RDS group was lower than that in control group (t=2.682,P＜0.05),and CPAP time,oxygen therapy days,intravenous nutrition days,hospitalization time were significantly longer than those in control group (t=2.969,2.380,2.571,1.999,P＜0.05).Binary logistic regression analysis showed that vitamin D deficiency was risk factors for RDS in preterm infants (OR=0.050,95%CI:0.013-0.186). Conclusions Preterm infants with low vitamin D level may increase the incidence of RDS.So it is of great significance for prevention of vitamin D deficiency.