长链非编码RNA与子宫内膜癌关系的研究进展

子宫内膜癌是妇科常见的恶性肿瘤之一,其发病率逐年增长。长链非编码RNA(lncRNA)是非编码RNA家族的成员之一,近年研究发现其在子宫内膜癌的病理过程中发挥重要的调控作用,成为研究热点。lncRNA可作为促进基因,通过人类第10号染色体上磷酸酶和张力蛋白同源缺失的基因/磷脂酰肌醇3激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白(PTEN/PI3K/AKT/mTOR)、Wnt/β连环蛋白(Wnt/β-Catenin)、细胞外信号调节激酶/腺苷酸活化蛋白激酶(ERK/AMPK)等多种信号通路调控子宫内膜癌细胞的增殖、迁移、侵袭、凋亡过程,亦可通过PTEN/PI3K/AKT/mTOR途径抑制子宫内膜癌过程。在lncRNA调控子宫内膜癌的过程中,形成的lncRNA-miRNA轴可作为未来干预治疗的新方向。lncRNA还可影响化疗药的耐药性,并对子宫内膜癌的诊断和预后有重要价值。综述近年lncRNA和子宫内膜癌的研究,为lncRNA对于子宫内膜癌的诊断、预后或治疗靶点提供理论依据。

Long Non-Coding RNA and Endometrial Cancer: A Review

Endometrial cancer is one of the common malignant tumors in gynecology, and its incidence is increasing year by year. Long non-coding RNA(lncRNA) is a member of the non-coding RNA family. In recent years, it has been found that it plays an important regulatory role in the pathological process of endometrial cancer and has become a research hotspot. Lnc RNA can be used as a promoter gene via human chromosome 10 deletion with phospho-and tensin homologue/phosphatidylinositol-3 kinase/protein kinase B/mammalian rapamycin target protein(PTEN/PI3 K/AKT/mTOR), Wnt/β-catenin(Wnt/β-Catenin), extracellular signalregulated kinase/adenylate-activated protein kinase(ERK/AMPK) and other signaling pathways to regulate proliferation, migration,invasion, and apoptosis of endometrial cancer cells. Lnc RNA can also inhibit the process of endometrial cancer through the PTEN/PI3 K/AKT/mTOR pathway. In the process of lnc RNA regulation of endometrial cancer, the formation of lnc RNA-miRNA axis can be used as a new direction for future intervention therapy. Lnc RNA can also affect the drug resistance of chemotherapeutic drugs, and has important value for the diagnosis and prognosis of endometrial cancer. This review summarizes the recent studies of lnc RNA and endometrial cancer, providing a theoretical basis for the diagnosis, prognosis or therapeutic targets of endometrial cancer.