傅里叶域OCT对不同屈光状态非青光眼青年人群神经节细胞复合体的观察

目的：应用傅里叶域光学相干断层扫描（OCT）观察不同屈光状态非青光眼青年人群神经节细胞复合 体（GCC）形态特征，探讨眼轴长度（AL）与GCC的变化规律。方法：病例对照研究。基于AL纳入非 高度近视94眼和高度近视62眼，使用OCT测量其黄斑区GCC厚度、上/下半区GCC（GCC-S/GCC-I） 厚度、局部丢失体积（FLV）和整体丢失体积（GLV）并计算FLV与GLV比值（FGR）。使用线性回归 分析各指标与AL的相关性；采用受试者工作特征曲线下面积（AUC）评价2组间各指标差异及界值。 结果：线性回归结果示受试者GCC厚度（β=-0.698，P<0.001）、GCC-S厚度（β=-0.693，P<0.001）、 GCC-I厚度（β=-0.672，P<0.001）随AL延长而下降；FLV不随AL变化而变化（β=0.115，P=0.155）； GLV随AL延长而增高（β=0.346，P<0.001），FGR随AL延长而降低（β=-0.473，P<0.001）。独立样 本t检验结果示高度近视组和非高度近视组间GCC厚度（t=7.398，P<0.001）、GCC-S厚度（t=7.313， P<0.001）、GCC-I厚度（t=7.022，P<0.001）、GLV（t=-3.482，P=0.001）及FGR（t=5.361，P<0.001） 差异有统计学意义，FLV差异无统计学意义（t=1.057，P=0.292）。AUCGCC为0.809（P<0.001），最佳 界值99 μm；AUCGLV为0.689（P<0.001），最佳界值3.42；AUCFGR为0.711（P<0.001），最佳界值0.44； AUCFLV为0.546（P=0.330）。结论：OCT可观察不同屈光状态非青光眼青年人群GCC，平均GCC厚度、 GCC-S厚度、GCC-I厚度、GLV和FGR随AL变化而发生改变。

Study of the Ganglion Cell Layer in Non-Glaucomatous Youth with Different Refractions Using Fourier-Domain Optical Coherence Tomography

Objective: To observe the ganglion cell complex (GCC) in non-glaucomatous youth with different refractions using Fourier-domain optical coherence tomography (FD-OCT), and to explore the association between axial length (AL) and GCC parameters. Methods: This was a cross-sectional, observational study. Ninety-four youth (94 eyes) were enrolled in a non-high myopia group and 62 youth (62 eyes) were enrolled in a high myopia group based on AL. The mean macular GCC thickness, superior-half GCC (GCC-S) thickness, inferior-half GCC (GCC-I) thickness, focal loss volume (FLV), global loss volume (GLV) and their ratio (FLV/GLV ratio, FGR) were measured. Linear regression was performed to analyze the correlation between AL and these parameters. The cut-off levels of the GCC parameters between the two groups were analyzed with the area under the curve (AUC) of the receiver operating functions. Results: Linear regression showed that the mean macular GCC thickness (β=-0.698, P<0.001), GCC-S thickness (β=-0.693, P<0.001) and GCC-I thickness (β=-0.672, P<0.001) are reduced as AL increases; FLV (β=0.115, P=0.155) was not significantly correlated with AL; GLV (β=0.346, P<0.001) was positively correlated while FGR (β=-0.473, P<0.001) was negatively correlated with AL. A t-test revealed that there are significant differences in the mean macular GCC thickness (t=7.398, P<0.001), GCC-S thickness (t=7.313, P<0.001), GCC-I thickness (t=7.022, P<0.001), GLV (t=-3.482, P<0.001) and FGR (t=5.361, P<0.001) between the high myopia and non-high myopia groups except for FLV (t=1.057, P=0.292). AUCGCC was 0.809 (P<0.001) and the best differential point was 99 μm; AUCGLV was 0.689 (P<0.001) and the best differential point was 3.42; AUCFGR was 0.711 (P<0.001) and the best differential point was 0.44; while AUCFLV was 0.546 (P=0.330). Conclusions: GCC parameters in non-glaucomatous youth can be evaluated by using FD-OCT, and some parameters change as the AL elongates.