肿瘤抗血管内皮生长因子与放射及免疫联合治疗研究进展

目前的很多基础研究和临床研究,都在探讨血管内皮生长因子(VEGF)抑制剂与放疗、免疫治疗相结合的作用机制、联合方案、治疗疗效和不良反应等,现有研究证实抗VEGF治疗可以提高放疗对肿瘤的控制,但怎样在疗效最大化、伤害最小化的基础上将这3种治疗手段合理运用,仍有待进一步探索。本文将对抗VEGF治疗与放疗、免疫治疗联合抗肿瘤的相关机制及研究进展作一综述。

Research progress on anti-vascular endothelial growth factor therapy,radiotherapy and immunotherapy for tumors

At present, in many preclinical and clinical studies, the mechanism of action, combination therapy, therapeutic efficacy, and side effects ofvascular endothelial growth factor(VEGF) inhibitors in combination with radiotherapy and immunotherapy are being explored. Some studies have reported improved tumor control after the addition of anti-VEGF intervention to radiotherapy. Nevertheless, how to administer these three modalities to achieve optimal response with minimal toxicity remains to be investigated. In this article, the mechanism and research progress on anti-VEGF therapy, radiotherapy and immunotherapy were reviewed.