维生素D缺乏与心脑血管疾病关系的研究进展

维生素D是一种类固醇激素，可通过与维生素D受体结合来影响心肌细胞、内皮细胞、血管 平滑肌细胞和炎症细胞，发挥抑制心肌肥厚、保护血管内皮、调节炎症反应的功能，进而改善心脑血 管疾病的发病风险及患者预后。维生素D缺乏可增加卒中患者的死亡风险，但应用维生素D补充剂与 脑血管疾病患者预后的关系目前仍不确定。本文对维生素D缺乏与心脑血管疾病之间关系的研究进 展进行综述。

Progress in the Relationship between Vitamin D Deficiency and Cardio-cerebrovascular Diseases

Vitamin D is a steroid hormone, it can affect cardiomyocytes, endothelial cells,
vascular smooth muscle cells and inflammatory cells by binding to the vitamin D receptors, and
then can play the following roles: inhibit cardiac hypertrophy, protect vascular endothelium,
regulate inflammatory reaction, which will reduce the risk of cardio-cerebrovascular diseases and
improve the patients’ prognosis. Vitamin D deficiency may increase the risk of death in stroke
patients. However, the relationship between vitamin D supplements and the prognosis of patients
with cerebrovascular disease is still uncertain. This paper reviewed the research progress of the
relationship between vitamin D deficiency and cardio-cerebrovascular diseases.