血管平滑肌脂肪瘤病理组织亚型及临床特点

目的 对全身56例血管平滑肌脂肪瘤(AML)进行分类,探讨其各个组织亚型的临床病理及免疫组织化学特点.方法 对全身56例AML患者进行临床病理回顾性分析,并进行组织亚型分类及免疫组织化学检查.结果 56例AML中,发生在肾脏43例,发生在肝脏9例,发生在腹膜后3例,发生在结肠1例.三相型43/56(76.9%);单相型6/56(10.7%);上皮样型6/56(10.7%);AML伴上皮囊肿1/56(1.7%).免疫组织化学染色显示:55例(98.2%)表达HMB45,54例(96.4%)表达Melan-A,28例(50.0%)表达CD1a,Ki-67的表达比例不一,CD34全部呈阴性表达.结论 AML可分为4种组织类型但诊断免疫标记相似,特征性表达HMB45、Melan-A、CD1a,手术效果均好.

Pathologic Histological subtypes and clinical characteristics of angiomyolipoma

Objective To investigate the clinicopathological and immunohistochemical characteristics of angiomyolipoma (AML) subtypes. Methods A retrospective study was done by subclassifying the 56 cases of AML, and clinicopathological investigation and immunohistochemical staining were also performed. Results Among the 56 cases, 43 eases were developed in the kidney, 9 cases in the liver, 3 eases in the retroperitoneal space, and one case in the colon. Forty-three cases (43/56, 76.9% ) were at tributed to the triphasic subtype, 6 cases (6/56, 10. 7%) to monophasic subtype, 6 cases (6/56,10. 7% ) to epithelioid subtype, and one case ( 1/56, 1.7% ) to AML with epithelial cyst formation. Immunohistochemically, 55 cases (55/56, 98.2% ) were positive for HMB45, 54 cases (54/56, 96. 4% )for Melan-A, and 28 cases (28/56, 50. 0% ) for CD1a. The expression rate of Ki-67 was variable case by case. GD34 was always negative. Conclusion The AMLs could be subclassified into 4 subtypes with the similar immunostaining labels including HMB45, Melan-A, and CD1 a. The outcome of AML is always good after surgical therapy.