| 顶空气相色谱法测定双氯西林钠中残留溶剂 |
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| 引用本文： | 汪洋,闵盛. 顶空气相色谱法测定双氯西林钠中残留溶剂[J]. 四川生殖卫生学院学报, 2009, 0(4): 41-42 |
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| 作者姓名： | 汪洋 闵盛 |
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| 作者单位： | 成都市食品药品检测中心,四川·成都610045 |
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| 摘 要： | 目的：建立双氧西林钠中残留溶剂的测定方法。方法：采用顶空进样毛细管气相色谱法，FID检测器，应用HP-5毛细管柱（30m×0．32μm×0．5μm），我气为氮气，柱温采用程序升温，初始温度30℃，保持5min，然后10℃／min的速率升温至135℃。测定了双氯西林钠中的乙酸乙酯和丙酮的残留量。结果：乙酸乙酯和丙酮能有效分离，在所考察的浓度范围内线性关系良好，r均为0．9998。结论：本方法灵敏、准确、可靠，可作为双氯西林钠中的残留溶剂的检测。
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| 关 键 词： | 顶空气相色谱法 双氯西林钠 残留溶剂 |
Determination of Residual Solvent in Dicioxacillin Sodium by Headspace Gas Chromatography |
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| WANG Yang,MIN Sheng. Determination of Residual Solvent in Dicioxacillin Sodium by Headspace Gas Chromatography[J]. Journal of Sichuan Reproductive Health Institute, 2009, 0(4): 41-42 |
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| Authors: | WANG Yang MIN Sheng |
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| Affiliation: | (Sichuan Institute for Food and Drug Control, Chengdu , Sichuan , 610045) |
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| Abstract: | Objective： To establish a method for the determination of ethyl acetate and acetone in dicloxacillin sodium. Methods： Using HP-5 capillary column （30m×0.32μm×0.5μm）, FID detector and programmable temperature. The initial temperature was kept at 30℃ for 5mitt, then the temperature was raised to 135℃ at the rate of 10℃/min. Results： There was a good linearity （r=0. 9998, 0. 9998） and the two residual solvent completely separated. The average recovery rate was in the range of 99. 0%-101.3%. Conclusion.. The method proved is proved to be convenient, accurate and rapid. |
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| Keywords: | headspace capillary gas chromatography dicloxacillin sodium residual solvent |
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