格拉司琼预防腹腔镜阑尾切除术后恶心呕吐的观察

目的评价格拉司琼预防腹腔镜阑尾切除术后恶心呕吐(PONV)的效果。方法将50例腹腔镜下进行阑尾切除术患者随机分为A、B两组,A组为格拉司琼组,B组为对照组,每组25例。A组在手术结束时静脉注射格拉司琼3 mg,B组静脉注射生理盐水20 mL。观察术后24 h恶心呕吐发生率。结果 A组患者PONV发生率明显低于B组,差异有统计学意义(P<0.05)。结论格拉司琼可以减少腹腔镜阑尾切除术患者PONV的发生。

Observation on granisetron for preventing postoperative nausea and vomiting in laparoscopic appendectomy

Objective To evaluate the efficacy of granisetron in prevention of postoperative nausea and vomiting（PONV） of laparoscopic appendectomy. Methods 50 cases of laparoscopic appendectomy were randomly divided into 2 groups with 25 cases in each group. The group A was intravenously given granisetron 3 nag at the completion of surgery,while the group B was intravenously given normal saline 20 mL at the end of operation. The incidence rate of PONV were observed from the end of operation to 24 h ＇after surgery. Results The incidence rate of PONV in the group A was sgnificantly lower than that in the group B with statistical difference between them（P〈0,05）. Conlusion Granisetron can decrease the occurrence of PONV after laparoscopic appendectomy.