| 超滤去除红霉素发酵液乳化现象的研究 |
| |
| 引用本文： | 冯建立,许振良,王学军,杨志和,臧文生. 超滤去除红霉素发酵液乳化现象的研究[J]. 中国抗生素杂志, 2007, 32(3): 150-153 |
| |
| 作者姓名： | 冯建立 许振良 王学军 杨志和 臧文生 |
| |
| 作者单位： | 1. 华东理工大学化学工程研究所膜科学与工程研发中心,上海,200237
2. 河南天方药业股份有限公司,驻马店,463000 |
| |
| 摘 要： | 目的开发一种超滤法去除红霉素发酵液处理过程中乳化现象的新工艺。方法采用自制的三种中空纤维超滤膜（UF-1、UF-2和UF-3）对红霉素发酵液去除乳化现象进行了试验。结果在优化的操作条件下，UF-3膜能够去除红霉素发酵液中蛋白质等引起乳化的杂质，超滤膜可以再生使用。结论超滤法可达到去除乳化的目的，同时提高了萃取的收率和质量。
|
| 关 键 词： | 超滤 发酵液 乳化 红霉素 预处理 |
| 文章编号： | 1001-8689(2007)03-0150-04 |
| 修稿时间： | 2006-05-09 |
Study on the demulsification of erythromycin fermentation broth by ultrafiltration |
| |
| Feng Jian-li,Xu Zhen-liang,Wang Xue-jun,Yang Zhi-he,Zang Wen-sheng. Study on the demulsification of erythromycin fermentation broth by ultrafiltration[J]. Chinese Journal of Antibiotics, 2007, 32(3): 150-153 |
| |
| Authors: | Feng Jian-li Xu Zhen-liang Wang Xue-jun Yang Zhi-he Zang Wen-sheng |
| |
| Abstract: | Objective To develop a new process used for demulsification of erythromycin fermentation broth by ultrafiltration membrane technique.Methods Three self-made hollow fiber ultrafiltration membranes(UF-1,UF-2 and UF-3) were tested to remove impurities which caused emulsification,e.g.protein,in the fermentation broth.Results The experiments under optimum operation conditions indicates that UF-3 is practicable to remove protein and polysaccharide which were the main cause of emulsitication of erythromycin fermentation broth,and the membrane could be recycled for using. Conclusions Ultrafiltration method could be employed to demulsification successfully.At the same time,it could improve the yield and quality of extraction. |
| |
| Keywords: | Ultrafiltration Fermentation broth Emulsification Erythromycin Pretreatment |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
