Effects of intermittent haloperidol treatment on dopamine receptor sensitivity in guinea pigs |
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| Authors: | William C. Koller |
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| Affiliation: | (1) School of Medicine, Lovola University, Chicago, Illinois, USA;(2) Present address: Neurology Service (127), VA Hospital, 60141 Hines, IL, USA |
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| Abstract: | Intermittent haloperidol treatment in guinea pigs caused an increase in the behavioral response to apomorphine and an increase in 3H-spiroperidol binding in the striatum to the same degree as continual haloperidol treatment. These results do not support the claim that drug holidays can reduce the incidence of tardive dyskinesia. |
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| Keywords: | Tardive dyskinesia Neuroleptics Dopamine receptors Drug holiday |
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