黄芪预防肿瘤坏死因子-α所致胰岛素抵抗

目的：探讨黄芪对大鼠注射肿瘤坏死因子－α（ＴＮＦ－α）后发性胰岛素抵抗（ＩＲ）的预防作用方法：取正常大鼠分别给予黄芪煎剂和等量蒸馏水预先灌胃１周，尾泳注射小剂量ＴＮＦ－α４ｈ后，以葡萄糖－胰岛素耐量试验（Ｇ－ＩｎｓＴＴ）检测其胰岛素敏感性等一些指标的变化。结果：外生ＴＮＦ－α可致正常大鼠出现高胰岛素血症，胰岛素敏感性Ｋ值下降，并有血浆胰高血糖素、促蛹 腺皮质激素和血脂水平的升高，肝脏和红色股四头肌

Preventive effect of radix Astragali on insulin resistance caused by tumor necrosis factor-alpha]

OBJECTIVE: To investigate the preventive effect of Radix Astragali (RA) on insulin resistance caused by tumor necrosis factor-alpha (TNF-alpha). METHODS: Normal rats were pretreated with RA or distilled water by intragastric infusion for one week. Glucose-insulin tolerance test was conducted in the rats 4 h after low dose TNF-alpha injection by caudal vein to estimate the change in insulin sensitivity. Meanwhile, the plasma glucagon, ACTH, blood lipid, and glycogen, triglyceride in tissue were also observed. RESULTS: Exogenous TNF-alpha could induce hyperinsulinemia in normal rats. K value in glucose-insulin tolerance test decreased, serum ACTH, glucagon, blood lipid increased, glycogen content in liver and red quadriceps muscles decreased, the liver triglyceride level increased in the TNF-alpha treated rats. RA could improve all the above-mentioned changes significantly except the blood lipid and triglyceride depots in liver. CONCLUSION: RA has obvious preventive effect on insulin resistance caused by TNF-alpha, it may be due to its action in decreasing insulin antagonistic hormones and increasing glycogen synthesis in tissue.