Evaluation of cognitive and psychomotor effects of nisoldipine or placebo in healthy volunteers

The purpose of this study was to compare the cognitive and psychomotor effects of the calcium antagonist nisoldipine with placebo in healthy volunteers over the three-week period of this randomised, double-blind, parallel group trial. Thirty volunteers received either a twice-daily dose of 10 mg nisoldipine or placebo. Psychometric testing and measurement of blood pressure and heart rate were carried out on days 0, 7, 14 and 21. Psychometric testing included: Critical Flicker Fusion (CFF), Choice Reaction Time (CRT), Digit Span (DS), Digit Symbol Substitution Test (DSST), and Letter Cancellation (LC). No significant treatment effects were found. CFF performance improved for both groups during the first week. In the CRT task, significant improvements were observed on days 14 and 21, relative to baseline, for total and motor reaction time. Similar improvements over time were found on the LC and DSST tasks. There were no significant differences between the active treatment and placebo for heart rate and systolic/diastolic blood pressure and nisoldipine was well tolerated. The results of this study indicate that nisoldipine does not have any cognition enhancing properties but, unlike some calcium antagonists, it does not markedly impair CNS activity. Copyright 2000 John Wiley & Sons, Ltd.