新生儿肺炎58例病原学分析

[目的]了解新生儿肺炎病原学分布及临床特点.[方法]对2007年9月至2008年8月本院儿科医学中心住院临床诊断为新生儿肺炎58例患儿,采集鼻咽部分泌物,进行痰细菌培养及呼吸道病毒核酸检测,分析病原学分布及临床特点.[结果]58例患儿39例病毒检出阳性或痰细菌培养阳性,病原检出率67.2%,其中痰细菌培养及呼吸道病毒检...

Etiological Analysis of 58 Cases of Neonatal Pneumonia

[Objective] To understand the pathogen distribution and clinical characteristics of newborn pneumonia. [Methods] Totally 58 pediatric patients clinically diagnosed as newborn pneumonia in our hospital from Sept. 2007 to Aug. 2008 were enrolled in this study. Nasopharyngeal aspirate specimens were collected for bacterial culture and the detection of respiratory virus nucleic acid. The pathogen distribution and clinical characteristics were analyzed. [Results] Among 58 cases, the virus or sputum bacterial culture were positive in 39 cases, and the overall positive rate was 67.2%. The detection rate of both sputum bacterial culture and respiratory virus was 46.6%. Sputum culture showed that KlebsieUa pneumoniae （48.1%） was the most common. The main viruses were RSV（40.7%） and HRV（22. 2%）. The late newborns older than 7 days were easier to have viral infection than the early newborns （X^2 = 6. 843, P =0. 009）. The pediatric patients with viral infection were easier to be accompanied by myocardial damage than the pediatric patients without viral infeetion（z2 =6. 416, P =0. 011）. [Conclusion] The pathogens of 67.2% newborn pneumonia can be confirmed. The main bacterium is Klebsiella pneumoniae, and the main viruses are RSV and HRV. Respiratory viruses are the important pathogens of newborn pneumonia especially late newborn pneumonia. Infectious patients are usually accompanied by myocardial damage.