Relationship of Pregnancy-Associated Alpha2-Glycoprotein (α2PAG) to Peripheral Blood Leucocytes |
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| Authors: | C. H. W. HORNE A. W. THOMSON C. M. TOWLER F. K. MacMILLAN L. M. GIBB |
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| Affiliation: | Department of Pathology, University Medical Building, Foresterhill, University of Aberdeen, Aberdeen, Scotland |
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| Abstract: | The high molecular weight plasma glycoprotein pregnancy-associated alpha2-glycoprotein (alpha2-PAG) can be demonstrated on the surface of blood leucocytes and is synthesized by oestrogen-stimulated cells in culture. By the use of an indirect immunofluorescence technique, pretreatment of leucocytes with anti-alpha2-PAG IgG revealed alpha2-PAG on C3 rosette-forming cells and monocytes but not on E rosettes. Lymphocytes treated with anti-alpha2-PAG showed markedly diminished ability to form Fc rosettes. A percentage ranging from 15% to 20% of leucocytes from normal adults of both sexes, pregnant and oestrogen-treated females were positive for alpha2-PAG but no obvious correlatin was observed between the incidence of alpha2-PAG bearing cells and plasma levels of the protein. |
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