Regional White Matter Signal Abnormalities and Cognitive Correlates Among Geriatric Patients with Treated Cardiovascular Disease |
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| Authors: | David F Tate Angela L Jefferson Adam M Brickman Karin F Hoth John Gunstad Kathryn Bramley Robert H Paul Athena Poppas Ronald A Cohen |
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| Institution: | (1) Department of Radiology, Center for Neurological Imaging, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA;(2) Department of Neurology, Alzheimer’s Disease Center, Boston University School of Medicine, Boston, MA, USA;(3) Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA;(4) Department of Medicine, Division of Psychosocial Medicine, National Jewish Health, Denver, CO, USA;(5) Department of Psychiatry, University of Colorado Denver, Denver, CO, USA;(6) Department of Psychology, Kent State University, Kent, OH, USA;(7) Department of Psychology, Behavioral Neuroscience, University of Missouri-St. Louis, St. Louis, MO, USA;(8) Section of Cardiology, Rhode Island Hospital, Warren Alpert School of Medicine at Brown University, Providence, RI, USA;(9) Department of Psychiatry and Human Behavior, Butler Hospital, Warren Alpert School of Medicine at Brown University, Providence, RI, USA;(10) Center for Neurological Imaging, Brigham and Women’s Hospital, 221 Longwood Ave, Boston, MA 02115, USA |
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| Abstract: | The purpose of this study was to investigate the relations between regional white matter signal abnormalities (WMSA) and cognitive
functioning among individuals being treated for cardiovascular risk factors and/or clinical events. Forty-one participants
with cardiovascular disease underwent a comprehensive neuropsychological assessment and MRI. Total WMSAs were quantified using
a semi-automated thresholding technique. Unique to this study, total WMSA volume was divided into three separate anatomically
related regions: WMSA in the periventricular (PERIWMSA) region, WMSA adjacent to subcortical nuclei (SUBWMSA), and WMSA in
the deep white matter (DEEPWMSA). A ratio of these measures to total cerebral brain volume was compared to cognitive measures
assessing attention, executive functioning, psychomotor speed, immediate and delayed memory, language, and visuospatial functioning.
PERIWMSA, SUBWMSA, and total WMSA were significantly associated with performance on measures of attention/processing speed.
No other significant relationships between WMSA and cognition were noted. Secondary analyses suggested that PERIWMSA volume
was increased in individuals with clinical evidence of atherosclerosis. These results emphasize the utility of studying the
associations between regional WMSA and cognitive/functional performance in patients undergoing cardiovascular treatment. |
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| Keywords: | Cardiovascular disease MRI Hyperintensities Cognition |
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