超敏C-反应蛋白与冠状动脉病变程度的相关性分析

目的探讨血清超敏C-反应蛋白(hs-CRP)与冠状动脉(冠脉)病变程度的相关性。方法对67例患者行冠脉造影,对造影结果采用Gensini积分定量评价冠脉血管病变程度;常规测定血清hs-CRP、血脂、血糖、尿酸和体重指数。两组间采用t检验,多组间比较采用方差分析,以Gensini积分与危险因素行多因素逐步回归分析。结果冠心病组与非冠心病组血清hs-CRP浓度比较,差异有统计学意义,P<0.05。3支冠脉病变组与正常冠脉、1支及2支病变组之间血清hs-CRP浓度差异均有统计学意义,P<0.05;而正常冠脉与1支及2支、1支与2支病变组之间差异无统计学意义。Gensini积分与hs-CRP有相关性,偏相关系数为0.623,P=0.000。结论hs-CRP与冠脉狭窄程度有相关性,在冠心病的发生、发展中起一定作用。

Relationship between hs-c-reactive protein and severity of coronary artery disease

Objective To investigate the relationship between the hs-c-reactive protein and the severity of coronary artery disease.Methods All the 67 patients underwent coronary angiography and measured risk factors,the Gensini score was used to determine the results of the coronary angiography.The t test,One-Way ANOVA and multiple linear regression analysis were used to predict hs-CRP.Results Coronary artery disease group hs-CRP levels were significantly higher than those in non-coronary artery disease group(P<0.05).hs-CRP were associated with the Gensini score(P=0.000).Conclusion The hs-CRP levels correlated with coronary artery stenosis severity and may play a role in proceeding and developing of coronary artery disease.