Pancreatic secretion in man with subclinical vitamin D deficiency |
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Authors: | B L Nyomba J Auwerx V Bormans T L Peeters W Pelemans J Reynaert R Bouillon G Vantrappen P De Moor |
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Institution: | (1) Laboratorium Experimentele Geneeskunde en Endocrinologie, Belgium;(2) Gut Hormone Laboratory, Belgium;(3) Geriatric Unit, Universitaire Ziekenhuizen, Katholieke Universiteit Leuven, Belgium;(4) Universitair Psychiatrisch Centrum St. Jozef, Kortenberg, Belgium |
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Abstract: | Summary The effects of subclinical vitamin D deficiency and vitamin D supplementation on oral glucose tolerance and secretion of pancreatic
hormones were studied in 10 diphenyl-hydantoin-treated epileptic patients and 15 geriatric patients. Their mean serum concentrations
of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 decreased markedly, but returned to normal within 2 weeks of oral supplementation with 25-hydroxyvitamin D3. The serum concentration of ionized calcium was within the normal range before treatment, and remained unchanged. Serum parathyroid
hormone was increased during vitamin D deficiency, but decreased significantly (p < 0.05) afterwards. In vitamin D-deficient epileptic and geriatric patients, the 2- and 3-h insulin levels after glucose
ingestion were increased when compared with control values, and glucagon secretion was not suppressed by glucose. Oral glucose
tolerance of both groups of patients did not change after 25-hydroxyvitamin D3 supplementation. Insulin secretion remained unchanged in geriatric patients, but was reduced to normal values in epileptic
patients. Glucagon suppressibility by glucose was partly restored after vitamin D supplementation in epileptic patients but
not in geriatric patients. In contrast to that observed in severely vitamin D-deficient rats or rabbits, correction of subclinical
vitamin D deficiency failed to enhance insulin secretion or to improve glucose tolerance in man. |
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Keywords: | Vitamin D calcium insulin glucagon glucose anticonvulsants geriatrics |
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