Prevention of 6-hydroxydopamine neurotoxicity. |
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| Authors: | G Cohen B Allis B Winston C Mytilineou R Heikkila |
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| Affiliation: | Department of Neurology, Mount Sinai School of Medicine, Fifth Avenue and 100 Street, New York, New York 10029, U.S.A. |
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| Abstract: | 1-Phenyl-3-(2-thiazolyl)-2-thiourea (PTTU) prevented the neurotoxic actions of 6-hydroxydopamine on adrenergic nerves in the mouse atrium and iris. This is the first reported 6-hydroxydopamine antagonist that does not act by blocking uptake of catecholamines into nerve terminals. PTTU also prevented the diabetogenic action of alloxan. |
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| Keywords: | Phenylthiazolylthiourea Neurotoxicity 6-Hydroxydopamine Alloxan Diabetes |
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