| 脑脉通注射液对大鼠局灶性脑缺血的影响 |
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| 引用本文： | 王庆杨,吴玉林,张丽娜.脑脉通注射液对大鼠局灶性脑缺血的影响[J].中国新药杂志,2008,17(21). |
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| 作者姓名： | 王庆杨 吴玉林 张丽娜 |
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| 作者单位： | 中国药科大学生理教研室,南京,210009 |
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| 摘 要： | 目的:研究脑脉通注射液对局灶性脑缺血的保护作用.方法:采用大鼠大脑中动脉阻塞(MCAO)模型,观察脑脉通对脑缺血大鼠神经行为、脑含水量、脑梗死体积、脑生化指标和脑组织病理变化的影响.结果:脑脉通注射液能改善MCAO大鼠神经行为,降低脑含水量,减少脑梗死体积比,提高ATP酶、超氧化物歧化酶(SOD)的活性,降低丙二醛(MDA)的含量,改善脑组织神经细胞缺血后病理改变.结论:脑脉通注射液可对抗缺血性脑损伤.
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| 关 键 词： | 脑脉通注射液 局灶性脑缺血 脑梗死 |
Protective effects of Naomaitong injection on focal cerebral ischemia in rats |
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| WANG Qing-yang,WU Yu-lin,ZHANG Li-na.Protective effects of Naomaitong injection on focal cerebral ischemia in rats[J].Chinese Journal of New Drugs,2008,17(21). |
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| Authors: | WANG Qing-yang WU Yu-lin ZHANG Li-na |
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| Institution: | Department of Physiology;China Pharmaceutical University;Nanjing 210009;China |
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| Abstract: | Objective:To determine the protective effects of Naomaitong injection on focal cerebral ischemia in rats.Methods: Focal cerebral ischemia was induced by middle cerebral artery occlusion.The effect of Naomaitong injection on behaviors,cerebral water content,infarct volume,biochemical and pathologic changes in the brain were evaluated.Results: Naomaitong injection improved behavior deficits,and decreased cerebral water content and infarction volume.It also increased ATPase and SOD activities,decreased MDA con... |
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| Keywords: | Naomaitong injection focal cerebral ischemia cerebral infarction |
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