| 血小板糖蛋白多态性与缺血性卒中 |
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| 引用本文： | 李湘青,韩红星,张晨. 血小板糖蛋白多态性与缺血性卒中[J]. 国际脑血管病杂志, 2004, 12(6): 437-441 |
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| 作者姓名： | 李湘青 韩红星 张晨 |
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| 作者单位： | 255006,山东省淄博市中心医院神经内科;266003,青岛大学医学院附属医院神经内科 |
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| 摘 要： | 血小板糖蛋白 (GP)是一种存在于血小板质膜表面的糖蛋白 ,在血小板活化和血栓形成过程中起关键作用。GP受体的基因突变必然影响血小板表面受体的表达数量与质量 ,从而影响血小板聚集。因此 ,GP与血栓性疾病的发生、发展密切相关 ,研究其基因多态性及其与缺血性卒中的关系 ,将为缺血性卒中的早期诊断和防治提供分子遗传学基础。
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| 关 键 词： | 缺血性卒中 血小板 糖蛋白 基因多态性 |
| 修稿时间： | 2003-05-19 |
Platelet Glycoprotein Polymorphisms and Ischemic Stroke |
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| Li Xiangqing ,Han Hongxing ,Zhang Chen. Platelet Glycoprotein Polymorphisms and Ischemic Stroke[J]. International Journal of Cerebrovascular Diseases, 2004, 12(6): 437-441 |
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| Authors: | Li Xiangqing Han Hongxing Zhang Chen |
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| Affiliation: | Li Xiangqing 1,Han Hongxing 2,Zhang Chen 2 1Department of Neurology,Zibo Municipal Central Hospital,Shandong 255006,China, 2Department of Neurology,the Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China |
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| Abstract: | Platelet glycoprotein (GP) is a kind of GP that presents on the surface of platelet membrane. It plays a key role in the processes of platelet activation and thrombosis. The gene mutations of GP receptors inevitably influence the expression of quantity and quality in platelet surface receptors, and thus affect platelet aggregation. Therefore, GP is closely associated with the onset and development of thrombotic diseases. To study GP gene polymorphism and its relations with ischemic stroke will provide the basis of molecular genetics in early diagnosis and treatment of ischemic stroke. |
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