伏立康唑药动学主要影响因素及特殊人群药动学特征研究进展

伏立康唑（voriconazole）是一种新型的三唑类抗真菌药，主要用于治疗侵袭性曲霉菌和念珠菌引发的感染，特别是对耐氟康唑的白色念珠菌有极好疗效，目前已广泛应用于临床。掌握和了解其药动学特征及其影响因素对于临床给药方案的选择和调整具有重要的指导意义。从伏立康唑药动学主要影响因素以及特殊人群的药动学特征两个方面对其药动学行为进行比较和分析，为临床安全、合理用药提供理论依据。

Advances in studies on pharmacokinetics of Vorieonazole

Voriconazole, as a new type of triazole antifungal drug, has been widely applied in clinic, mainly used in the treatment of infection caused by invasive Aspergillus and Candidal, especially the fluconazole resistance of Candidal albicans. Grasp and understand its pharmacokinetic characteristics and the influence factors have important significance for the clinical dosage regimen and adjustment. In this article, the influence factors of voriconazole and pharmacokinetic characteristics of special population have been reviewed, which may provide theoretical basis for clinical pharmacotherapy of safety and rationality.