99Tcm-MDP SPECT/CT融合显像诊断骨纤维异常增殖症

目的 探讨⁹⁹Tc^m-MDP SPECT/CT融合显像诊断骨纤维异常增殖症（FD）的临床应用价值。方法 回顾性分析13例FD患者的临床和⁹⁹Tc^m-MDP SPECT/CT融合显像资料，其中11例经病理证实为FD，2例经随访确诊。所有患者均有原发肿瘤病史。结果 13例FD均为单发，位于颅面骨10例，位于肋骨、坐骨及胫骨骨干各1例。全身骨显像定性诊断准确率为38.46%（5/13），SPECT/CT断层融合显像定性诊断准确率为69.23%（9/13）；92.31%（12/13）的患者全身骨显像表现为中-高代谢；CT征象中，磨玻璃密度影（GGO）和骨质膨胀分别占84.62%（11/13）和76.92%（10/13），溶骨性破坏、硬化边分别占53.85%（7/13）、30.77%（4/13），13例均未见骨皮质破坏。结论 ⁹⁹Tc^m-MDP SPECT/CT断层融合显像可综合提供功能和解剖学信息，有助于FD的诊断。骨显像中-高代谢及GGO和骨质膨胀的CT征象常提示FD。

99Tcm-MDP SPECT/CT imaging in diagnosis of fibrous dysplasia

Objective To explore the clinical application of ⁹⁹Tc^m-MDP SPECT/CT imaging in diagnosing fibrous dysplasia (FD). Methods Clinical and ⁹⁹Tc^m-MDP SPECT/CT imaging data of 13 patients with FD were retrospectively studied. There were 11 cases confirmed by biopsy or surgery, and 2 cases diagnosed by radiologic examination and follow-up. All the patients had history of known cancer. Results All the lesions of FD were monostotic and most frequently found in craniofacial region (n=10) while infrequently found in rib (n=1), ischium (n=1) and long bone (n=1). The qualitative diagnosis accuracy of whole-body bone scan (WBBS) was 38.46% (5/13), as while as that of SPECT/CT imaging was 69.23% (9/13). And 92.31% (12/13) of the lesion showed moderate or high metabolic on WBBS images. Among the features of CT, ground-glass opacity (GGO) and bone expansion were found in 84.62% (11/13) and 76.92% (10/13), while lytic lesions and sclerosis were found in 53.85% (7/13) and 30.77% (4/13). There was no bone destruction in any patients. Conclusion ⁹⁹Tc^m-MDP SPECT/CT imaging can be used to provid function and anatomy informations of FD which is helpful for diagnosis. The features of moderate or high metabolic on WBBS, GGO and bone expansion usually indicate FD.