脉络宁注射液联合单唾液酸四己糖神经节苷脂钠治疗高血压脑出血的疗效观察

目的探究脉络宁注射液联合单唾液酸四己糖神经节苷脂钠治疗高血压脑出血的临床疗效。方法选取2014年3月—2015年4月四川省安岳县人民医院神经外科接受治疗的高血压脑出血患者86例,按照治疗方法的不同分为对照组和治疗组,每组各43例。对照组患者静脉输注单唾液酸四己糖神经节苷脂钠注射液,100 mg加入到0.9%Na Cl溶液250 m L中,1次/d。治疗组在对照组基础上静脉输注脉络宁注射液,20 m L加入到0.9%Na Cl溶液100 m L中,1次/d。两组患者均治疗14 d。观察两组的临床疗效,比较两组患者血肿量、血肿周围水肿量及美国国立卫生研究院卒中量表(NIHSS)评分变化。结果治疗后,对照组和治疗组的总有效率分别为76.74%、93.02%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者血肿量、血肿周围水肿量及MIHSS评分明显下降,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论脉络宁注射液联合单唾液酸四己糖神经节苷脂钠治疗高血压脑出血具有较好的临床疗效,能迅速减少颅内血肿,减轻血肿周围水肿,减轻脑损伤,提高患者的生活质量,具有一定的临床推广应用价值。

Clinical observation of Mailuoning Injection combined with monosialotetrahexosylganglioside sodium in treatment of hypertensive intracerebral hemorrhage

Objective To investigate the clinical effect of Mailuoning Injection combined with monosialotetrahexosylganglioside sodium in treatment of hypertensive intracerebral hemorrhage. Methods Patients (86 cases) with hypertensive intracerebral hemorrhage in Department of Neurosurgery of Sichuan Anyue County People''s Hospital from March 2014 to April 2015 were enrolled in this study. According to the different treatment plans, the patients were divided into control and treatment groups, and each group had 43 cases. Patients in the control group were iv administered with Monosialotetrahexosylganglioside Sodium Injection, 100 mg added into normal saline 250 mL, once daily. Patients in the treatment group were iv administered with Mailuoning Injection on the basis of the control group, 20 mL added into normal saline 100 mL, once daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the changes of hematoma volume, perihematomal edema volume, and NIHSS scores in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.74% and 93.02%, respectively, and there was difference between two groups (P<0.05). After treatment, hematoma volume, perihematomal edema volume, and NIHSS scores in two groups were significantly decreased, and the differences were statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Mailuoning Injection combined with monosialotetrahexosylganglioside sodium has clinical curative effect in treatment of hypertensive intracerebral hemorrhage, and can rapidly reduce intracranial hematoma, reduce perihematomal edema, reduce brain damage, and improve quality of life, which has a certain clinical application value.