硝苯地平联合倍他乐克对原发性高血压患者的疗效观察

目的 探析硝苯地平控释片联合倍他乐克治疗原发性高血压的临床疗效。方法 将100例渭南市妇幼保健院住院部收治的原发性高血压患者按随机频数表均分为观察组和对照组各50例，观察组以硝苯地平控释片和倍他乐克治疗，对照组只以硝苯地平控释片处理，治疗前后均对两组患者的24 h动态血压、心率及不良反应详细记录，连续治疗8周后，对比各项指标的变化分析治疗效果及安全性。结果 治疗后两组患者24 h收缩压、舒张压和心率均明显下降，与治疗前比较差异显著（P<0.05）。治疗后，观察组24 h收缩压、舒张压和心率均明显低于对照组，差异显著（P<0.05）。观察组收缩压和舒张压的谷峰比均明显高于对照组，差异显著（P<0.05），表明观察组血压控制更平稳。连续治疗8周后，观察组总有效率为96.0%，对照组总有效率为78.0%，两组比较差异有统计学意义（P<0.05）。观察组不良反应率8%明显低于对照组的22%，两组比较差异有统计学意义（P<0.05）。结论 硝苯地平控释片联合倍他乐克治疗原发性高血压不仅有效，而且大大降低了药物的副作用，是临床的合理选择。

Efficacy of nifedipine combined with metoprolol in treatment of essential hypertension

Objective To analyze the clinical effect of Nifedipine Controlled Release Tablets with metoprolol on treatment of essential hypertension. Methods Totally 100 cases of patients with essential hypertension were randomly divided into observation group and control group, 50 cases in each group. The patients in observation group were treated with Nifedipine Controlled Release Tablets and metoprolol, and the patients in control group were only treated with Nifedipine Controlled Release Tablets. Then the 24-h ambulatory blood pressure, heart rate, and adverse reaction in both groups before and after treatment were observed. After 8 weeks of continuous treatment, the therapeutic effect and safety of the changes of indexes were analyzed. Results After treatment, the 24 h systolic pressure, diastolic pressure, and heart rate of two groups were significantly decreased than before treatment (P<0.05). The 24 h systolic pressure, diastolic pressure, and heart rate of observartion group were significantly lower than those in the control group (P<0.05). The systolic pressure, diastolic pressure trough-to-peak ratios of observation group were significantly higher than those of the control group (P<0.05). The blood pressure of observation group was controlled more smoothly. After treatment for 8 weeks, the total efficacy of observation group was 96.0%, while the control group was 78.0%, which had significant difference (P<0.05). The adverse reaction rate of observation group was 8%, while that in the control group was 22%, which had significant difference (P<0.05). Conclusion Nifedipine Controlled Release Tablets combined with metoprolol in the treatment of primary hypertension is not only effective, but also greatly reduces the side effects of drugs, and it is a reasonable choice.