| 食管癌变过程中PLCE1蛋白的表达 |
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| 引用本文： | 赵学科,周福有,张连群,王建坡,张朋,王能超,杜娴娟,宋昕,申芳芳,王立东.食管癌变过程中PLCE1蛋白的表达[J].河南大学学报(医学版),2012(3):203-205. |
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| 作者姓名： | 赵学科 周福有 张连群 王建坡 张朋 王能超 杜娴娟 宋昕 申芳芳 王立东 |
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| 作者单位： | 郑州大学第一附属医院河南省食管癌重点开放实验室;新乡医学院癌症研究中心;河南省安阳市肿瘤医院 |
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| 基金项目： | 国家科技部863重大项目(2012AA02A503);国家自然科学基金项目(30971133);河南省卫生科技创新人才项目(3047) |
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| 摘 要： | 目的探讨PLCE1蛋白的表达变化与食管鳞状细胞癌(esophageal squamous cell carcinoma,ESCC)发生的关系。方法选择138例ESCC患者手术切除标本的正常、癌旁及癌组织,采用免疫组织化学ABC法检测PLCE1蛋白的表达。结果 PLCE1蛋白在正常食管鳞状上皮、癌前病变和癌组织中的阳性表达率分别为41%、82%和83%(P<0.05);高发区/低发区及家族史阳性/家族史阴性亚组分析PLCE1蛋白阳性表达率无差异(P>0.05)。结论 PLCE1蛋白和ESCC癌变有关,PLCE1可能作为致病基因促进ESCC的发生发展。
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| 关 键 词： | 食管癌 PLCE1蛋白 免疫组织化学 |
Expression of PLCE1 protein in esophageal multistage carcinogenesis |
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| ZHAO Xue-ke,ZHOU Fu-you,ZHANG Lian-qun,WANG Jian-po,ZHANG Peng,WANG Neng-chao,DU Xian-juan,SONG Xin,SHEN Fang-fang,WANG Li-dong.Expression of PLCE1 protein in esophageal multistage carcinogenesis[J].Journal of Henan University,2012(3):203-205. |
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| Authors: | ZHAO Xue-ke ZHOU Fu-you ZHANG Lian-qun WANG Jian-po ZHANG Peng WANG Neng-chao DU Xian-juan SONG Xin SHEN Fang-fang WANG Li-dong |
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| Institution: | 1,2(1.Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital,Zhengzhou University,Zhengzhou,Henan 450052,China;2.Cancer Research Center,Xinxiang Medical University,Xinxiang,Henan 453003,China;3.Anyang Tumor Hospital,Anyang,Henan 455000,China) |
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| Abstract: | Objective To characterize the expression of PLCE1 protein in multistage carcinogenesis of esophageal squamous cell carcinoma(ESCC).Methods Immunohistochemical analysis of PLCE1 expression was carried out in paraffin-embedded sections of the normal esophageal squamous epithelium,precancerous lesion and cancer tissues from ESCC cases(n=138).Results The positive protein immunostaining expression rates for PLCE1 were 41%,82% and 83% in the normal esophageal squamous epithelium,precancerous lesion and cancer tissues,respectively(P<0.05).Furthermore,the rates in cancer were not of statistical significance in the high/low incidence areas,positive/negative family history(P>0.05).Conclusions The results showed that overexpression of PLCE1 protein may participate in esophageal carcinogensis,and PLCE1 may be a pathogenic gene to promote the development of ESCC. |
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| Keywords: | esophageal squamous cell carcinoma PLCE1 protein immunohistochemistry |
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