阿立哌唑对心电图Tp-Te间期的影响

目的观察抗精神病药阿立派唑对精神分裂症患者Tp-Te间期的影响。方法收集35例应用抗精神病药阿立派唑和26例应用氯氮平治疗的首发精神分裂症患者,氯氮平组给予氯氮平200~400mg口服,阿立哌唑组给予阿立哌唑20~30mg口服,治疗前及治疗4周后分别记录同步12导联心电图,对Tp-Te间期进行手工测量,计算校正的TP-TE间期(Tp-Te/√RR),并进行组间比较。结果治疗4周后,氯氮平组的Tp-Te间期及Tp-Tec间期与治疗前相比较明显延长,且与阿立哌唑组相比较具有统计学意义(p<0.05)。结论与氯氮平相比,阿立哌唑对心电图Tp-Te间期及Tp-Tec间期的影响较小,安全性相对较大。

Effects of aripiprazole on the Tp-Te interval in first episode schizophrenia patients

Objective To study the effects of aripiprazole on the Tp-Te interval in first episode schizophrenia patients. Methods All patients with first-episode schizophrenia were divided into two groups treated with aripiprazole(n=35) or clozapine(n=26). The changes of Tp-Te interval and corrected Tp-Te interval were observed before and after 4 weeks treatment. Results After 4 weeks treatment, the Tp-Te interval and corrected Tp-Te interval were prolonged than before treatment in clozapine group,and there were significant diference in the two groups(p<0.05), but there were no significant difference in aripiprazole groups(p>0.05). Conclusion Compared to clozapine, aripiprazole had less effect on the Tp-Te interval in first episode schizophrenia patients and was much safer for treatment.