睡眠剥夺对健康青年糖代谢的影响

目的 研究睡眠剥夺对健康青年志愿者糖代谢的影响. 方法 对象为40名血糖代谢正常的青年健康志愿者,其中男22名,女18名,年龄19～35岁.于睡眠剥夺前后行口服葡萄糖耐量试验,取血测定血糖和胰岛素,用稳态模式评估法2公式计算胰岛素抵抗指数、胰岛素敏感指数和胰岛β细胞功能. 结果 睡眠剥夺后与睡眠剥夺前空腹胰岛素水平差异无统计学意义(P>0.05).睡眠剥夺后空腹血糖、糖负荷后2 h血糖、胰岛素抵抗指数均显著高于睡眠剥夺前测定值(t=2.189～7.721,P<0.05),胰岛素敏感指数、胰岛β细胞功能睡眠剥夺后均显著低于睡眠剥夺前测定值(t=2.189、6.575,P<0.05). 结论 睡眠剥夺后胰岛β细胞功能受抑,胰岛素抵抗发生.睡眠剥夺影响机体糖代谢,对飞行人员应该进行应对性预防研究.

Effects of sleep deprivation on glucose metabolism in healthy youth volunteer

Objective To investigate the effects of sleep deprivation (SD) on glucose metabolism in healthy youth. Methods Forty normal glucose tolerated young volunteers (male 22, female 18, aged 19-35) were chosen. Plasma glucose and insulin levels were measured during oral glucose tolerance test before and after SD for 40 volunteers who were with of normal glucose tolerance. Insulin sensitivity and insulin resistance was assessed by homeostasis model assessment 2. Insulin resistance index (IRI), insulin sensitivity index (ISI), and islet β cell function (HOMA-β) were calculated. Results There was no significant difference in fasting plasma insulin concentration (P>0.05 ). Fasting plasma glucose, 2nd hour plasma glucose (2hPG) and IRI before SD were significantly higher than those after SD (t=2.189-7.721, P<0.05). ISI, HOMA-β before SD were significant lower compared with those after SD (t= 2. 189,6. 575,P<0.05). Conclusions SD can cause HOMA-β inhibition and insulin resistance. Attention should be paid to the aircrew who are suffering from SD and at high risk of diabetes mellitus.