环氧合酶-2在胃癌中的表达及预后意义

目的:研究环氧合酶-2(COC-2)在胃癌、不典型增生及慢性萎缩性胃炎中的表达情况,探讨COX-2表达的预后意义。方法经手术病理证实的早、中期胃癌281例,进行预后随访调查。232例进行免疫组织化学染色。检则COX-2在胃癌及非癌组织中的表达情况,分析其与预后的关系。结果:早期胃癌的5年生存率为93.4％,中期胃癌的5年生存率为59.0％。COX-2在慢性萎缩性胃炎中的表达明显低于不典型增生者(P<0.01),在癌组织中的表达明显高于非癌组织(P<0.05～0.01);COX-2与胃癌淋巴结转移、血管浸润均密切相关(P<0.01);COX-2阳性表达者5年生存率明显低于阴性者(P<0.01)。结论:COX-2在胃癌组织呈过度表达状态,与胃癌的生长和浸润转移关系密切,可以作为反映胃癌生物学行为和判断预后的有效指标。

Expression of Cyclooxygenase- 2 and Prognostic Signficance in Human Gastric Carcinoma

Purpose: To investigate the expression of cydooxygenasel-2(COX-2), in chronic atrophic gastritis, gastric mucosa! atypical hyperplasia, early and middle stage of gastric carcinoma, to identify the prognotic significance of COX-2 expression. Methods: 281 patients with early and middle stage of gastric carcinoma who underwent surgical resection were followed up. Expression of COX-2 was examined by immunohistocheinistry in 232 archival paraf-fmembedded tissue specimens and control groups. Results; 5-years sinvival rates of early and middle stage of gastric carcinoma were 93.4% and 59.0% , respectively. Expression of COX-2 was significantly higher in mucosal atypical hyperplasia than that in chronic atrophic gastritis (P < 0.01) . Compared with paired noncancerous specimens, COX - 2 levels in carcinoma tissue were significantly higher (/*<().05 ~0.01). Expression of COX-2 was highly correlated with lymph node metastasis and vascular invasion (P< 0.01). 'llie 5-years sumval rate in the patients with COX-2 expression was much lower than the rate in those patiants without CXO-2 expression(P < 0.01} Conclusion; Overexpression of COX-2 in patients with gastric carcinoma can enhance the possibility of invasion anil metastasis, implicating a poor prognosis. It may serve as the fairly good prognosic factors to indicate biologic behavior anil prognosis in gastric carcinoma.