Effect of continued rt-PA administration on the residual stenosis after initially successful recanalization in acute myocardial infarction - a quantitative coronary angiography study of a randomized trial |
| |
Authors: | SERRUYS, P. W. ARNOLD, A. E. R. BROWER, R. W. DE BONO, D. P. BOKSLAG, M. LUBSEN, J. REIBER, J. H. C. RUTSCH, W. R. UEBIS, R. VAHANIAN, A. VERSTRAETE, M. THE EUROPEAN CO-OPERATIVE STUDY GROUP FOR RECOMNINANT TISSUE-TYPE PLASMINOGEN ACTIATOR, |
| |
Abstract: | Quantitative angiography was performed in 68 out of 123 patientstreated with intravenous rt-PA for acute myocardial infarction.At 90 min angiography, the median minimal cross-sectional areawas 1.11 mm2 and the median percentage area stenosis was 80%.A percentage area stenosis greater than 70% was seen in 78%of the patients. Patients with a patent infarct related artery at the first angiogramwere randomized to receive subsequent infusions either of rt-PA+ heparin or placebo + heparin. There was a persistent trendof improvement in minimal lumen diameter and percentage diameterstenosis of the residual stenosis in the infarct related arteryin both treatment groups when re-examined 624 hours laterand at the time of hospital discharge. A reduction in plaquearea, the area between the detected and the referencecontours of the infarct related segment, was more frequentlyseen in patients receiving a second infusion of rt-PA than inpatients with no prolonged thrombolytic therapy (83% versus57%, P<0.025, chi square). |
| |
Keywords: | rt-PA myocardial infarction reocclusion quantitative coronary angiography |
本文献已被 Oxford 等数据库收录! |
|