Sleep rebound attenuates context-dependent behavioural sensitization induced by amphetamine |
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| Authors: | Calzavara Mariana Bendlin Andersen Monica Levy Fukushiro Daniela Fukue Lopez Giorgia Batlle Abílio Vanessa Costhek Tufik Sergio Frussa-Filho Roberto |
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| Affiliation: | 1. Department of Pharmacology, Universidade Federal de São Paulo, Rua Botucatu, 862, Edifício Leal Prado, CEP 04023-062 São Paulo, SP, Brazil;2. Department of Psychobiology, Universidade Federal de São Paulo, Brazil Rua Napoleão de Barros, 925 Vila Clementino, São Paulo, SP, Brazil |
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| Abstract: | We have recently demonstrated that paradoxical sleep deprivation (PSD) potentiates the induction of amphetamine (AMPH)-induced behavioural sensitization by increasing its conditioned component. In the present study, the effects of sleep rebound (induced by 24 h recovery period from PSD) were studied on AMPH-induced behavioural sensitization. Sleep rebound attenuated the acute locomotor-stimulating effect of AMPH. AMPH-induced behavioural sensitization was context-specific and was also attenuated by sleep rebound. These results strengthen the notion that sleep conditions can influence AMPH-induced behavioural sensitization. |
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| Keywords: | ACTH, adrenocorticotropic hormone AMPH, amphetamine HC, home-cage OF, open-field PSD, paradoxical sleep deprivation PSR, paradoxical sleep rebound SAL, saline. |
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