| 隆突性皮肤纤维肉瘤中PTEN的表达 |
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| 引用本文： | 赖宽,李顺凡,吴国凤.隆突性皮肤纤维肉瘤中PTEN的表达[J].岭南皮肤性病科杂志,2005,12(1):1-4. |
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| 作者姓名： | 赖宽 李顺凡 吴国凤 |
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| 作者单位： | 广东医学院附属医院皮肤科,广东,湛江,524001 |
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| 摘 要： | 目的:观察隆突性皮肤性纤维肉瘤中PTEN的表达情况,探讨它的意义.方法:使用免疫组化结合图像分析法检测39例隆突性皮肤纤维肉瘤(DFSP)、30例皮肤纤维瘤(DF)中CD34、PTEN的表达情况.结果:CD34蛋白在DFSP中表达明显高于在DF的表达;而PTEN蛋白在DFSP中的表达低于DF，差异具有统计学意义（P＜0.05) .直线相关分析表明:CD34和PTEN蛋白的表达之间无相关性(P＞0.05).结论:PTEN与隆突性皮肤纤维肉瘤的发生、发展密切相关,除CD34外,可作为隆突性皮肤纤维肉瘤与皮肤纤维瘤鉴别的参考指标.
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| 关 键 词： | 肉瘤 隆突性皮肤纤维肉瘤 皮肤纤维瘤 |
| 文章编号： | 1009-8968(2005)01-0001-04 |
| 修稿时间： | 2004年10月18 |
Quantitative Dectection of PTEN Protein in Dermatofibrosarcoma Protuberans |
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| KAI Kuan,LI Shun-fan,WU Guo-feng.Quantitative Dectection of PTEN Protein in Dermatofibrosarcoma Protuberans[J].Southern China Journal of Dermato-Venereology,2005,12(1):1-4. |
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| Authors: | KAI Kuan LI Shun-fan WU Guo-feng |
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| Abstract: | Objective:To investigate the expression of PTEN (phosphatase and tensin homology deleted on chromosometen) in dermatofibrosarcoma protuberans(DFSP),and to study its significance. Methods:The expression of CD34,PTEN protein was detected by immunohistochemical in paraffin-embedded specimens of 39 DFSP and 30 dermatofibromas(DF). All of the results were quantitatively analyzed by image analysis system. Results:The expression of CD34 protein in DFSP was higher than that in the DF (P<0.05), whereas the expression of PTEN protein in DFSP was lower than that in the DF(P<0.05), and there was no correlation between the expression of these two proteins. Conclusion:PTEN is related with the occurrence and development of DFSP, and it may be helpful in diagnosis of DFSP when it is hard to make a diagnosis between DFSP and DF. |
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| Keywords: | CD34 PTEN |
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