| Effect of Corocinnarine on Physiological Characteristics of Guinea Pig Papillary Muscles |
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| 引用本文： | 陈水英,赵德化,盛宝恒. Effect of Corocinnarine on Physiological Characteristics of Guinea Pig Papillary Muscles[J]. 中国人民解放军军医大学学报, 1990, 0(3) |
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| 作者姓名： | 陈水英 赵德化 盛宝恒 |
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| 作者单位： | Department of Pharmacology Fourth Military Medical University，Xi'an 710032，Department of Pharmacology，Fourth Military Medical University，Xi'an 710032，Department of Pharmacology，Fourth Military Medical University，Xi'an 710032 |
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| 摘 要： | In our experiment it was found that,in guinea pig papillary muscles,8205 de-creased the automaticity and prolonged the functional refractory period(FRP)as well asdecreased the contractile amplitude dose-dependently,but exerted no effect on the excitabili-ty.The dose-response curves of isoproterenol shifted to the right in parallel manner,inaccordance with competitive antagonistic,but the effect of 8205 was much less than thatof propranolol.Dose-response curves of CaCl_2 shifted to the right non-parallelly.The re-sults indicated that the mechanism of anti-arrhythmia of 8205 might be related to theCa~(2+)-antagonism.
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Effect of Corocinnarine on Physiological Characteristics of Guinea Pig Papillary Muscles |
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| Chen Shuiying Zhao Dehua Sheng Baoheng. Effect of Corocinnarine on Physiological Characteristics of Guinea Pig Papillary Muscles[J]. Journal of Medical Colleges of PLA(China), 1990, 0(3) |
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| Authors: | Chen Shuiying Zhao Dehua Sheng Baoheng |
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| Affiliation: | Chen Shuiying Zhao Dehua Sheng Baoheng Department of Pharmacology,Fourth Military Medical University,Xi'an 710032 |
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| Abstract: | In our experiment it was found that,in guinea pig papillary muscles,8205 de- creased the automaticity and prolonged the functional refractory period(FRP)as well as decreased the contractile amplitude dose-dependently,but exerted no effect on the excitabili- ty.The dose-response curves of isoproterenol shifted to the right in parallel manner,in accordance with competitive antagonistic,but the effect of 8205 was much less than that of propranolol.Dose-response curves of CaCl_2 shifted to the right non-parallelly.The re- sults indicated that the mechanism of anti-arrhythmia of 8205 might be related to the Ca~(2+)-antagonism. |
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| Keywords: | 8205 isoproterenol propranolol verapamil calcium chloride |
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