首页 | 本学科首页   官方微博 | 高级检索  
     


Sex differences in the performance of cognitive tasks in a murine model of metabolic syndrome
Authors:Claudia Espinosa‐Garcí  a,Claudia Erika Fuentes‐Venado,Christian Guerra‐Araiza,Julia Segura‐Uribe,Edwin Ch  vez‐Guti  rrez,Eunice Dalet Farf  n‐Garcí  a,Norma Ang  lica Estrada Cruz,Rodolfo Pinto‐Almaz  n
Affiliation:Claudia Espinosa‐García,Claudia Erika Fuentes‐Venado,Christian Guerra‐Araiza,Julia Segura‐Uribe,Edwin Chávez‐Gutiérrez,Eunice Dalet Farfán‐García,Norma Angélica Estrada Cruz,Rodolfo Pinto‐Almazán
Abstract:The metabolic syndrome includes changes in blood glucose levels, arterial hypertension, triglycerides, dyslipidemia and central obesity. Countless reports have described the correlation between the metabolic syndrome and cognitive impairment. However, only a few reports have assessed cognitive impairment associated with the metabolic syndrome in animals of both sexes. For this purpose, Sprague‐Dawley male and female rats were fed either with a hypercaloric diet as model of the metabolic syndrome or with a standard chow diet as controls. Subsequently, spatial learning and memory (Morris water maze) as well as short‐ and long‐term memory (passive avoidance task) were evaluated. Body weight, blood pressure, triglycerides, and total cholesterol significantly increased (F(1, 36) = 94.89, p < .001) in rats fed with hypercaloric diet compared to control rats. Furthermore, cognitive impairment was observed in spatial learning and spatial memory on male rats but not on female rats fed with hypercaloric diet. In addition, a long‐term memory impairment was observed in both groups fed with hypercaloric diet in comparison to their respective control group (F(1, 32) = 10.61, p = .0027). Immunohistochemistry results showed no changes in the number of positive cells for NeuN, GFAP and Ox‐42. In males fed with a hypercaloric diet, a decrease in testosterone levels was observed, whereas estradiol levels decreased in females when compared with their respective control group (p < .0001). In this MetS animal model, metabolic and cognitive differences were observed in males and females, which demonstrates that sex hormones play a significant role in metabolic regulation and neuroprotection related to the CA1 region of the hippocampus.
Keywords:hippocampus  memory  metabolic syndrome  sex differences  sex hormones
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号