| Abstract: | Ductal carcinoma in situ (DCIS) is a nonobligate precursor of invasive breast cancer. Current clinical trials are exploring active surveillance (AS) of DCIS. The purpose of this study is to characterize current practice trends in the use of AS. The findings may inform clinical trials and provide insight into factors influencing adoption into practice. The National Cancer Database was used to identify women diagnosed with DCIS from 2004 to 2015. Management with AS was defined as any patient not undergoing surgery, chemotherapy, or radiation therapy. Multivariable logistic regression was used to assess patterns of AS. Of 84 281 women with DCIS, 342 (0.4%) underwent AS. Increased age (OR 1.16, CI 1.15‐1.17), Hispanic or non‐Hispanic black ethnicities (OR 1.91 CI 1.42‐2.56; 1.54 CI 1.13‐2.10), treatment at an academic facility (OR 1.64 CI 1.31‐2.10), and low‐volume facilities (OR 1.60 CI 1.06‐2.42) were associated with an increased use of AS. Patients with ≥1 comorbidities (OR 0.70 CI 0.49‐0.98), high‐grade tumors (OR 0.671 CI 0.51‐0.89), and private insurance (OR 0.69 CI 0.53‐0.89) less frequently underwent AS. Of all patients undergoing AS, 11% received endocrine therapy. Active surveillance is currently an infrequently used treatment modality for patients with DCIS. We observed variations in AS based on age, ethnicity, comorbidities, facility type, facility volume, insurance status, and tumor grade. Most patients managed with AS did not receive hormone therapy. This information may further inform strategies for clinical trials, as well as guide quality of care in the adoption of future management options for DCIS. |
