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Wilson disease: copper deficiency and iatrogenic neurological complications with zinc therapy
Authors:Landy M. Wu  Adel Ekladious  Luke Wheeler  Abdulrazak A. Mohamad
Abstract:A 17‐year‐old female was diagnosed with Wilson disease and commenced on oral zinc therapy. She re‐presented 6 months later with a fall and had classical signs of subacute combined degeneration of the spinal cord confirmed on nerve conduction studies, as a result of zinc‐induced copper deficiency. After 6 months of copper therapy, she made a complete recovery with no residual neurological deficits. Early detection of zinc‐induced copper deficiency and stringent follow‐up mechanisms are crucial. Early initiation of copper replacement may both limit and completely reverse neurological deficits.
Keywords:Wilson disease  zinc  copper  subacute combined degeneration  neurological complication
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