一氧化氮在肿瘤性贫血患者中的表达 |
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引用本文: | 冯志刚,张成侠,刘艳芬,刘东芳,訾建杰. 一氧化氮在肿瘤性贫血患者中的表达[J]. 中国肿瘤临床与康复, 2014, 0(2): 204-205 |
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作者姓名: | 冯志刚 张成侠 刘艳芬 刘东芳 訾建杰 |
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作者单位: | 河北省唐山市人民医院血液科,唐山063001 |
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摘 要: | 目的研究肿瘤性贫血患者血清一氧化氮(NO)和一氧化氮合酶(NOS)的表达水平,探讨其与肿瘤性贫血的关系。方法选择2009年9月至2011年10月期间的肿瘤性贫血患者40例,为观察组;另外选择同期体检的健康人15例,为对照组。采用硝酸还原酶法测定NO和NOS含量。结果肿瘤性贫血患者NO和NOS水平明显高于正常对照(P<0.05);随着贫血程度加重,NO和NOS水平明显升高(P<0.05)。结论 NO在肿瘤性贫血的发病中起重要作用,及早降低NO水平,有助于阻止贫血的发展,可以为肿瘤性贫血的治疗提供新策略。
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关 键 词: | 肿瘤相关性贫血 血清 一氧化氮 |
Expression of nitric oxide levels in tumor patients with anemia |
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Affiliation: | FENG Zhi-gang, ZHANG Cheng-xia ,LIU Yan-fen ,et al ( Department of Hematology, People's Hospital of Tangshan, Tangshan 063001, China) |
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Abstract: | Objective To explore the expression level of nitric oxide (NO) and nitric oxide syn- dthase (NOS) in tremor patients with anemia, and the relationship with cancer-related anemia (CAR) Methods 40 patients with cancer-related anemia were enrolled in this study as observation group from September 2009 to October 2011, and 15 healthy subjects were collected as control group over the same pe- riod. Serum nitric oxide and nitric oxide synthase levels were assayed by the method of enzymsti- gense. Results The mean levels of serum NO and NOS in the observation group were higher than that in the control group, the difference was statistically significant ( P 〈 0. 05 ). Along with the increasing degree of a- nemia, the levels of NO and NOS rised obviously. Conclusions The NO plays an important role in the path- ogenesis of CAR, and reducing the level of NO is useful for preventing the progress of anemia, which will provide a new strategy for CAR therapy. |
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Keywords: | Cancer-related anemia Serum Nitric: oxide |
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