老年冠心病双联抗血小板治疗后上消化道出血的相关因素分析

目的分析老年冠心病(ACS)双联抗血小板治疗后上消化道出血的相关因素。方法选择我院2007年8月—2013年6月住院的因双联抗血小板治疗后上消化道出血老年ACS患者48例为出血组,选择同期住院治疗的老年ACS双联抗血小板治疗后未出血患者48例作为对照组。回顾性分析患者的临床资料,记录性别、年龄、肾功能、幽门螺杆菌(Hp)感染、负荷剂量、GRACE评分高危、联合口服质子泵抑制剂(PPI)、既往胃肠病史。结果出血组年龄、肾功能减退、Hp感染、负荷剂量、联合口服PPI、既往胃肠病史所占比例均高于对照组(P0.05)。两组患者性别和GRACE评分高危所占比例比较,差异无统计学意义(P0.05)。结论老年ACS双联抗血小板治疗后上消化道出血由多种原因引起,临床上应加强预防。

Analysis of Related Factors of Upper Gastrointestinal Bleeding on Elderly Patients with Coronary Heart Disease after Dual Antiplatelet Therapy

Objective To investigate the related factors of upper gastrointestinal bleeding on elderly patients with coronary heart disease（ ACS） after dual antiplatelet therapy. Methods 48 patients with ACS after dual antiplatelet therapy admitted to our hospital from August 2007 to June 2013 were selected as bleeding group,48 patients without bleeding at the same period were selected as control group. The gender,age,renal,Hp infection,loading dose,GRACE score,combined with PPI, previous history of gastrointestinal between two groups were analyzed. Results The age,kidney function,Hp infection,loading dose,combined with PPI,previous history of gastrointestinal in bleeding group were higher than those of control group（ P 0. 05）. The gender and GRACE score between two groups showed no significant difference（ P 0. 05）. Conclusion Upper gastrointestinal bleeding in elderly patients with ACS after dual antiplatelet therapy is caused by a variety of reasons,should be alert to clinical prevention of bleeding after treatment.