免疫组化标记物在子宫内膜样腺癌与宫颈腺癌鉴别诊断中的表达及意义

目的探讨免疫组化标记物波形蛋白(Vimentin)、癌胚抗原(CEA)、雌激素受体(ER)、孕激素受体(PR)和p16蛋白在子宫内膜样腺癌与宫颈腺癌鉴别诊断中的表达和意义。方法采用免疫组织化学染色法检测48例子宫内膜样腺癌和21例宫颈腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16的表达,并分析其临床意义。结果子宫内膜样腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16阳性表达率分别为79.2%、31.3%、87.5%、81.3%和20.8%。宫颈腺癌患者肿瘤组织中Vimentin、CEA、ER、PR和p16阳性表达率分别为14.3%、90.5%、23.8%、42.9%和81.0%。经2检验,Vimentin(2=25.50)、CEA(2=20.50)、ER(2=27.29)、PR(2=10.17)和p16(2=22.17)在子宫内膜样腺癌和宫颈腺癌患者肿瘤组织中阳性表达率的差异均有统计学意义(P<0.05)。结论免疫组化法检测Vimentin、CEA、ER、PR和p16的表达有助于临床鉴别诊断宫颈腺癌和子宫内膜样腺癌。

The expression and significiance of markers detected by immunohistochemistry in diagnosis and dif- ferential diagnosis of endometrial adenocarcinoma and cervical adenocarcinoma

Objective To investigate the expression and significiance of Vimentin, CEA, ER, PR and p16 detected by immunohistoehemistry in endometrial adenocareinoma and cervical adenocarcinoma. Methods To detect the expression of Vimentin, CEA, ER, PR and p16 in 48 eases of endometrial adenocarcinoma and 21 cases of cervical ad by immunohistochemical staining. Results The expression rates of Vimentin,CEA, ER,PR and p16 in the endometrial adenocarcinoma were 79. 2% ,31.3%, 87. 5% ,81.3% and 20. 8%. The expression rates of Vimentin,CEA, ER,PR and p16 in the cervical adenoearcinoma were 14. 3% ,90. 5% ,23.8% ,42. 9% and 81.0%. Conclusions pl6,Vimentin,CEA,ER and PR are useful to distinguish cervical adenoeareinoma and endometrial adenoeareinoma.