| 调节性B细胞与多发性硬化的研究进展 |
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| 引用本文： | 叶玲,李作孝. 调节性B细胞与多发性硬化的研究进展[J]. 实用心脑肺血管病杂志, 2014, 0(1): 5-7 |
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| 作者姓名： | 叶玲 李作孝 |
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| 作者单位： | 四川省泸州市,泸州医学院附属医院神经内科646000 |
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| 摘 要： | 调节性B细胞(Bregs)主要来源于边缘区B细胞和B1细胞,炎症微环境是其分化/激活所必需的。Bregs通过产生白介素10(IL-10)、转化生长因子β1(TGF-β1)等抑制性细胞因子和通过与T细胞等其他免疫细胞的相互作用来介导免疫耐受。在实验性自身免疫性脑脊髓炎(EAE)/多发性硬化(MS)中,Bregs通过产生IL-10及抑制病理性Th1/Th17细胞的应答,增强Th2细胞的负性调节作用来控制疾病的启动和减轻疾病的严重性。
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| 关 键 词： | B淋巴细胞 调节性 白介素10 转化生长因子pl 多发性硬化 |
Research of Regulatory B Cell and Multiple Sclerosis |
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| Affiliation: | YE Ling, LI Zuo -xiao. Department of Neurology, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China |
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| Abstract: | Regulatory B cells （Bregs） mainly come from marginal zone B cells and B1 cells, and inflammatory mi- croenvironment is required for its differentiation/activation. Bregs are capable to performing regulatory functions by production of inhibitory cytokines, such as interleukin - 10 （ IL - 10）, transforming growth factor - 131 （ TGF - ~l ）, or by interaction with other immune cells. In experimental autoimmune encephalomyelitis （EAE） /muhiple sclerosis （MS）, Bregs can prior to in- hibit the disease＇s occurrence and reduce the severity by producting IL - 10 and inhibiting Thl/Thl7. |
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| Keywords: | B -lymphocytes, regulatory Interleukin 10 Transforming growth factor betal Multiple sclerosis |
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