布地奈德联合特布他林雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效研究

目的探讨布地奈德(普米克令舒)联合特布他林(博利康尼)雾化吸入治疗慢性阻塞性肺疾病急性加重期(AECOPD)的疗效。方法选取我院2010年1月—2013年6月住院的AECOPD患者60例,将其随机分为观察组和对照组,各30例。在常规治疗基础上观察组用普米克令舒+博利康尼混合后雾化吸入,对照组用0.9%氯化钠溶液+庆大霉素注射液+α-糜蛋白酶+地塞米松雾化吸入,均治疗10 d。治疗前后对两组患者进行肺功能检查及动脉血气分析。结果治疗后,观察组第1秒用力呼气容积(FEV1)、用力肺活量(FVC)及FEV1/FVC均高于对照组(P0.05);喘息缓解时间、咳嗽消失时间及哮鸣音基本消失时间均短于对照组(P0.05);PaO2高于对照组,PaCO2低于对照组(P0.05)。结论普米克令舒与博利康尼联合使用能明显改善AECOPD患者肺功能、血气指标及临床症状,且安全性高,可作为AECOPD的常规治疗方法。

Effect of Budesonide Combined with Terbutaline Inhalation on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective To investigate the effect of Budcsocide（Pulmicort） combined with Terbutaline（Bricanyl） inhalation on acute exacerbation of ch,ronic obstructive pulmonary disease （AECOPD）. Methods 60 patients with AECOP admitted to,our hospital from January 2010 to June 2013 were randomly diviided into observation group and control group,, each of 30cases. Observation group was, given Pubnicort ＋ Bricanyl inhalation, control group was given saline ＋ gentamicin injection ＋ α - ehymotrypsin ＋ dexamethasone＇ inhalation, both treated for 10 days. The lung function and arterial blood gas were compared be- tween two groups before anti after treatment. Results After treatment, the forced expiratory volume in 1 secondl （FEV1） , forced vital capacity （FVC） and FEV1/FVC in observation group were higher than those of control group （P 〈 0. 05） ; the breathing remission time, coughing and wheezing disappeared time in observatiort group were shorter than those of control group （P 〈0. 05） ; the PaO2 was higher than that of control group, PaCO2 was lower than that of control group （P 〈0. 05）. Conclu- sion Pulmieort combined with Bricanyl inhalation can significantly improve lung function, blood gas indexes and clinical symp- toms in patients with AECOPD, is safe and can be used as conventional therapy.