依达拉奉联合高压氧治疗急性脑梗死的疗效观察

目的观察依达拉奉联合高压氧治疗急性脑梗死的疗效和安全性。方法选择2010年10月—2013年5月我院收治的急性脑梗死患者96例,将其随机分为治疗组56例和对照组40例。对照组给予常规治疗;治疗组除常规治疗外,给予依达拉奉联合高压氧治疗,均治疗20 d。观察两组治疗前后神经功能缺损评分和血液流变学指标,并比较两组疗效。结果治疗组总有效率为92.9%(52/56),高于对照组的80.0%(32/40)(P0.05)。治疗后治疗组神经功能缺损评分、全血比黏度、血浆比黏度、红细胞聚集指数、纤维蛋白原均低于对照组(P0.05)。两组均未出现明显不良反应。结论依达拉奉联合高压氧治疗急性脑梗死疗效显著,可以有效改善患者血液流变学,降低脑缺血后神经功能的损伤,且无明显不良反应。

Effect of Edaravone Combined with Hyperbaric Oxygen on Acute Cerebral Infarction

Objective To observe the clinical efficacy and safety of edaravone combined with hyperbaric oxygen on acute cerebral infarction. Methods 96 patients with acute cerebral infarction admitted to our hospital from October 2010 to May 2013 were randomly divided into treatment group （56 cases） and control group （40 cases）. Control group was given conven- tional treatment, treatment group was given edaravone and hyperbaric oxygen on basis of control group, both treated for 20 days. The neurological deficit scores, indexes of blood rheology and effect between two groups were compared before and after treat- ment. Results The total efficacy of treatment group was 92. 9% （52/56） , higher than that of the control group of 80. 0% （32/40） （P 〈0.05）. After treatment, the neurological deficit scores, blood viscosity, plasma viscosity, erythrocyte aggrega- tion index, fibrinogen in treatment group were lower than those of control group （P 〈 0. 05）. There was no obvious adverse reac- tions in 2 groups. Conclusion Edaravone combined with hyperbaric oxygen in treating acute cerebral infarction can effectively improve the blood rheology, reduce neurological damage, being obviously effective and safety.