蒿甲醚粉针剂对裸鼠体内移植人肺腺癌A549的抑制作用

目的探讨蒿甲醚粉针剂对裸鼠体内移植人肺腺癌A549的抑制作用。方法选取雌性裸鼠32只,将其随机分为对照组,低、中、高剂量组,各8只。裸鼠接种人肺腺癌A549细胞24 h后,高剂量组给予蒿甲醚粉针剂120 mg/kg、中剂量组为80 mg/kg、低剂量组为54 mg/kg,对照组给予0.9%氯化钠溶液10 mg/kg,连续给药12 d后处死裸鼠,剖取肿块称质量,计算抑瘤率。结果 4组抑瘤率比较,差异有统计学意义(P0.05),其中高剂量组抑瘤率高于低、中剂量组(P0.05),低、中剂量组抑瘤率比较,差异无统计学意义(P0.05)。结论裸鼠腹腔连续注射蒿甲醚粉针剂对人肺腺癌A549有抑制作用,随着剂量的增加抑制作用越强。

Inhibitory Effect of Artemether Injection on Transplanted Human Lung Cancer A549 in Nude Mice

Objective To investigate the inhibitory effect of artemether injection on transplanted human lung cancer A549 in nude mice. Methods 32 male nude mice were randomly divided into groups control, low dose, middle dose, high dose, each of 8 eases. 24 hours after inoculation of tumor, high dose group was taken artemether injection 120 mg/kg, middle dose group was taken 80 mg/kg, low dose group was taken 54 mg/kg, control group was taken 0. 9% sodium chloride solution 10 mg/kg. The nude mice were killed after continuous infusion for 12 days, and the tumor mass was weighed, inhibition rate was calculated. Results The inhibition rate of 4 groups showed statistically significantly differences （ P 〈 0.05 ）, thereinto inhibi- tion rate in high dose group was higher than that of low, middle dose groups （ P 〈 0.05 ）, there was no significantly difference in inhibition rate between low dose group and middle dose group （ P 〉 0. 05 ）. Conclusion Continuous artemether injection can restrain the human lung cancer A549 in nude mice, and the inhibitory effect enhaced with dose increasing.