联合检测神经元特异性烯醇化酶和癌胚抗原在肺癌与肺结核鉴别诊断中的价值

目的研究神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)联合检测对肺癌与肺结核的鉴别诊断价值,为肺癌与肺结核的鉴别诊断提供实验依据。方法选取2009年1月—2013年6月我院收治的肺结核患者42例(肺结核组)和肺癌患者39例(肺癌组),另选取同期在我院体检健康者42例作为对照组。采用放射免疫法(RIA)测定受试者NSE、CEA水平。结果肺癌组NSE、CEA水平高于肺结核组和对照组(P0.05)。腺癌患者CEA水平高于鳞状细胞癌和小细胞肺癌患者(P0.05),小细胞肺癌患者NSE水平高于鳞状细胞癌和腺癌患者(P0.05)。NSE诊断肺癌的敏感度为71.8%(28/39),特异度为88.1%(37/42);CEA诊断肺癌的敏感度为66.7%(26/39),特异度为78.6%(33/42);两项指标联合检测诊断肺癌的敏感度为92.3%(36/39),特异度为80.1%(34/42)。结论血清NSE、CEA检测可作为肺癌与肺结核鉴别诊断的实验室指标,且NSE、CEA联合检测可进一步提高诊断肺癌敏感度。

Differential Diagnosis Value of Combined Detection of Neuron - specific Enolase and Carcinoembryonic Antigen for LungCancer and Pulmonary Tuberculosis

Objective To investigate the differential diagnosis value of combined detection of neuron - specific eno- lase （NSE） and carcinoembryonic antigen （CEA） for lung cancer and tuberculosis, to provide experimental evidence. Methods 42 patients with tuberculosis （tuberculosis group） and 39 patients with lung cancer （lung cancer group） were selected from January 2009 to June 2013 in our hospital, 42 cases of heahhy people were selected as control group during corresponding period. The levels of NSE and CEA were determined by radioimmunoassay （RIA）. Results The levels of CEA and NSE in lung cancer group were higher than those of tuberculosis group and control group （P 〈 0. 05）. CEA levels in patients with adenocarcinoma were higher that of squamous cell carcinoma and small cell lung cancer （P 〈 0.05）, NSE levels in patients with small cell lung cancer was higher than that of squamous cell carcinoma and adenocarcinoma （ P 〈 0.05 ）. Susceptibility of NSE in lung cancer was 71.79% （28/39）, specificity was 88.1% （37/42） ; sensitivity Of CEA in lung cancer was 66. 7% （26/39）, specificity was 78.6% （33/42） ; and the sensitivity of combined detection in lung cancer was 92. 31% （36/39）, specificity was 80. 1% （34/42）. Conclusion Serum NSE, CEA testing can be used as laboratory parameters in differential diagnosis for lung cancer and tuberculosis, and combined detection can further improved the sensitivity.